Perkins Aster Q, Rich Erin L
bioRxiv. 2024 Nov 14:2024.11.12.623291. doi: 10.1101/2024.11.12.623291.
Economic decisions often require weighing multiple dimensions, or attributes. The orbitofrontal cortex FC) is thought to be important for computing the integrated value of an option from its attributes and comparing lues to make a choice. Although OFC neurons are known to encode integrated values, evidence for value mparison has been limited. Here, we used a multi-attribute choice task for monkeys to investigate how OFC eurons integrate and compare multi-attribute options. Attributes were represented separately and eye tracking as used to measure attention. We found that OFC neurons encode the value of attended attributes, dependent of other attributes in the same option. Encoding was negatively weighted by the value of the same tribute in the other option, consistent with a comparison between the two like attributes. These results indicate at OFC computes comparisons among attributes rather than integrated values, and does so dynamically, ifting with the focus of attention.
经济决策通常需要权衡多个维度或属性。眶额皮质（OFC）被认为对于根据选项的属性计算其综合价值并比较这些价值以做出选择很重要。虽然已知OFC神经元会编码综合价值，但价值比较的证据一直有限。在这里，我们使用了一个针对猴子的多属性选择任务来研究OFC神经元如何整合和比较多属性选项。属性被分别呈现，并且使用眼动追踪来测量注意力。我们发现，OFC神经元编码被关注属性的价值，这与同一选项中的其他属性无关。编码受到另一个选项中相同属性价值的负向加权影响，这与两个相似属性之间的比较一致。这些结果表明，OFC计算的是属性之间的比较而非综合价值，并且是动态进行的，随注意力焦点而转移。
