Attention-dependent attribute comparisons underlie multi-attribute decision-making in orbitofrontal cortex.

Economic decisions often require weighing multiple dimensions, or attributes. The orbitofrontal cortex FC) is thought to be important for computing the integrated value of an option from its attributes and comparing lues to make a choice. Although OFC neurons are known to encode integrated values, evidence for value mparison has been limited. Here, we used a multi-attribute choice task for monkeys to investigate how OFC eurons integrate and compare multi-attribute options. Attributes were represented separately and eye tracking as used to measure attention. We found that OFC neurons encode the value of attended attributes, dependent of other attributes in the same option. Encoding was negatively weighted by the value of the same tribute in the other option, consistent with a comparison between the two like attributes. These results indicate at OFC computes comparisons among attributes rather than integrated values, and does so dynamically, ifting with the focus of attention.