Sui Laijian, Wang Jing, Jiang Wen G, Song Xicheng, Ye Lin
Department of Orthopedics, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, United Kingdom.
Front Oncol. 2024 Nov 13;14:1401113. doi: 10.3389/fonc.2024.1401113. eCollection 2024.
Bone metastasis is a debilitating complication that frequently occurs in the advanced stages of breast cancer. However, the underlying molecular and cellular mechanisms of the bone metastasis remain unclear. Here, we elucidate how bone metastasis arises from tumor cells that detach from the primary lesions and infiltrate into the surrounding tissue, as well as how these cells disseminate to distant sites. Specifically, we elaborate how tumor cells preferentially grow within the bone micro-environment and interact with bone cells to facilitate bone destruction, characterized as osteoclastic bone metastasis, as well as new bone matrix deposition, characterized as osteoblastic bone metastasis. We also updated the current understanding of the molecular mechanisms underlying bone metastasis and reasons for relapse in breast cancer, and also opportunities of developing novel diagnostic approaches and treatment.
骨转移是一种使人衰弱的并发症，经常发生在乳腺癌晚期。然而，骨转移的潜在分子和细胞机制仍不清楚。在这里，我们阐明了骨转移是如何从脱离原发灶并浸润到周围组织的肿瘤细胞中产生的，以及这些细胞是如何扩散到远处部位的。具体来说，我们详细阐述了肿瘤细胞如何在骨微环境中优先生长，并与骨细胞相互作用以促进骨破坏（即破骨性骨转移）以及新骨基质沉积（即成骨性骨转移）。我们还更新了目前对乳腺癌骨转移潜在分子机制、复发原因的理解，以及开发新型诊断方法和治疗方法的机会。
