Zhu Runhe, Ni Jiawei, Ren Jiayin, Li Dongye, Xu Jiawei, Yu Xinru, Ma Ying Jie, Kou Luan
The Traditional Chinese Medicine College, Shandong University of Traditional Chinese Medicine, Jinan, China.
The Pharmacy College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Oncol. 2024 Nov 13;14:1464125. doi: 10.3389/fonc.2024.1464125. eCollection 2024.
In the era of transcriptomics, the role of epigenetics in the study of cancers in females has gained increasing recognition. This article explores the impact of epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNA, on cancers in females, including breast, cervical, and ovarian cancers (1). Our findings suggest that these epigenetic markers not only influence tumor onset, progression, and metastasis but also present novel targets for therapeutic intervention. Detailed analyses of DNA methylation patterns have revealed aberrant events in cancer cells, particularly promoter region hypermethylation, which may lead to silencing of tumor suppressor genes. Furthermore, we examined the complex roles of histone modifications and long non-coding RNAs in regulating the expression of cancer-related genes, thereby providing a scientific basis for developing targeted epigenetic therapies. Our research emphasizes the importance of understanding the functions and mechanisms of epigenetics in cancers in females to develop effective treatment strategies. Future therapeutic approaches may include drugs targeting specific epigenetic markers, which could not only improve therapeutic outcomes but also enhance patient survival and quality of life. Through these efforts, we aim to offer new perspectives and hope for the prevention, diagnosis, and treatment of cancers in females.
在转录组学时代,表观遗传学在女性癌症研究中的作用日益受到认可。本文探讨了DNA甲基化、组蛋白修饰和非编码RNA等表观遗传修饰对女性癌症(包括乳腺癌、宫颈癌和卵巢癌)的影响(1)。我们的研究结果表明,这些表观遗传标记不仅影响肿瘤的发生、进展和转移,还为治疗干预提供了新的靶点。对DNA甲基化模式的详细分析揭示了癌细胞中的异常事件,特别是启动子区域的高甲基化,这可能导致肿瘤抑制基因的沉默。此外,我们研究了组蛋白修饰和长链非编码RNA在调节癌症相关基因表达中的复杂作用,从而为开发靶向表观遗传疗法提供了科学依据。我们的研究强调了了解表观遗传学在女性癌症中的功能和机制对于制定有效治疗策略的重要性。未来的治疗方法可能包括针对特定表观遗传标记的药物,这不仅可以改善治疗效果,还可以提高患者的生存率和生活质量。通过这些努力,我们旨在为女性癌症的预防、诊断和治疗提供新的视角和希望。