Li Xue, Zhu Danxia
Oncology Department, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Oncol Lett. 2024 Nov 12;29(1):55. doi: 10.3892/ol.2024.14801. eCollection 2025 Jan.
The research field of regulated cell death is growing extensively. Following the recognition of ferroptosis, other unique and distinct forms of regulated cell death, including cuproptosis and disulfide death, have been identified. Disulfide death occurs due to the abnormal accumulation of disulfides within cells in environments lacking glucose, leading to contraction of the actin cytoskeleton, which ultimately triggers various signaling pathways and cell death. The induction of disulfide death in the treatment of cancer may exhibit significant therapeutic potential. Therefore, in the present review, a comprehensive and critical analysis of the current understanding of the molecular mechanisms and regulatory networks of disulfide death is presented. In addition, the potential physiological functions of disulfide death in tumor suppression and immune surveillance as well as its pathological roles and therapeutic potential are described. The core focus areas for future research into this form of cell death are also explored. Given the current lack of extensive clinical findings and well-defined key concepts, these may be regarded as pivotal points of interest in future studies.
细胞程序性死亡的研究领域正在广泛发展。继铁死亡被认识之后，其他独特且不同形式的细胞程序性死亡，包括铜死亡和二硫键死亡，也已被发现。二硫键死亡是由于在缺乏葡萄糖的环境中细胞内二硫键异常积累，导致肌动蛋白细胞骨架收缩，最终触发各种信号通路并导致细胞死亡。二硫键死亡在癌症治疗中的诱导可能具有显著的治疗潜力。因此，在本综述中，对目前对二硫键死亡的分子机制和调控网络的理解进行了全面且批判性的分析。此外，还描述了二硫键死亡在肿瘤抑制和免疫监视中的潜在生理功能及其病理作用和治疗潜力。还探讨了针对这种细胞死亡形式未来研究的核心重点领域。鉴于目前缺乏广泛的临床发现和明确的关键概念，这些可能被视为未来研究的关键关注点。
