Zhou Rong, Qin Yan, Hu Song, Xu Yangyang, Feng Chunlai
Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Department of Gastroenterology, Changzhou Maternal and Child Health Care Hospital, Changzhou, Jiangsu, China.
Future Oncol. 2024 Dec;20(40):3471-3476. doi: 10.1080/14796694.2024.2430164. Epub 2024 Nov 28.
This study analyzed the application of dual bronchodilators in patients with non-small cell lung cancer (NSCLC) & chronic obstructive pulmonary disease (COPD) during the perioperative period.
A total of 100 patients with moderate to severe COPD who underwent thoracoscopic lobectomy were divided into two groups. The patients in the observation group (group O) were treated with umeclidinium/vilanterol and conventional treatment (oxygen therapy, assisted expectoration, respiratory rehabilitation training) during the perioperative period. The patients in the control group (group C) received conventional treatment. Lung function, arterial blood gas values, quality of life, postoperative adverse reactions, days of postoperative chest tube placement and hospitalization were assessed.
Before surgery, group O presented higher FEV1, FVC, PEF and MVV, elevated PO and reduced PCO, lower CAT scores compared with the group C ( < 0.05). The group O demonstrated fewer perioperative adverse reactions, and shorter days of postoperative chest tube and hospitalization compared with the group C ( < 0.05).
Perioperative inhalation of umeclidinium/vilanterol can effectively protect arterial blood gas and respiratory function in patients with LC complicated with COPD.
本研究分析了双支气管扩张剂在非小细胞肺癌（NSCLC）合并慢性阻塞性肺疾病（COPD）患者围手术期的应用情况。
将100例行胸腔镜肺叶切除术的中重度COPD患者分为两组。观察组（O组）患者在围手术期接受乌美溴铵/维兰特罗及常规治疗（吸氧、辅助排痰、呼吸康复训练）。对照组（C组）患者接受常规治疗。评估肺功能、动脉血气值、生活质量、术后不良反应、术后胸腔闭式引流管留置天数及住院天数。
术前，O组的第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、呼气峰流速（PEF）及最大通气量（MVV）均高于C组，氧分压（PO）升高，二氧化碳分压（PCO）降低，慢性阻塞性肺疾病评估测试（CAT）评分低于C组（P<0.05）。与C组相比，O组围手术期不良反应较少，术后胸腔闭式引流管留置天数及住院天数较短（P<0.05）。
围手术期吸入乌美溴铵/维兰特罗可有效保护肺癌合并COPD患者的动脉血气及呼吸功能。
