Broughton Philip, Niles Addison, Imeh-Nathaniel Adebobola, Imeh-Nathaniel Samuel, Goodwin Richard L, Roley Laurie Theriot, Nathaniel Thomas I
University of South Carolina, School of Medicine-Greenville, 701 Grove Rd, Greenville, SC 29605, USA.
North Greenville University, 7801N Tigerville Rd, Tigerville, SC 29688, USA.
Geriatr Nurs. 2025 Jan-Feb;61:371-377. doi: 10.1016/j.gerinurse.2024.11.001. Epub 2024 Nov 27.
This study investigates risk factors in the population of Alzheimer disease (AD) patients with NPS (ADNPS).
Baseline risk factors associated with male and female ADNPS were examined using data from a regional AD care center. Univariate analysis was used to determine factors in male and female patients, while logistic regression models were developed to generate odds ratios (OR) to predict risk factors that are associated with male or female ADNPS.
In the adjusted analysis, dyslipidemia (OR = 0.630, 95 % CI, 0.431-0.992, P = 0.017), thyroid dysfunction (OR = 0.549, 95 % CI, 0.377-0.798, P = 0.002), and cerebral infarction (OR = 0.684, 95 % CI, 0.472-0.991, P = 0.0085) were associated with male ADNPS patients, whereas chronic heart failure (OR = 1.408, 95 % CI, 0.953-2.079, P = 0.0085) was associated with female ADNPS patients.
Our results reveal that female ADNPS patients were associated with heart failure, whereas male patients were associated with dyslipidemia and cerebral infarction.
本研究调查患有神经精神症状的阿尔茨海默病（AD）患者群体（ADNPS）中的风险因素。
利用一个地区性AD护理中心的数据，对与男性和女性ADNPS相关的基线风险因素进行检查。单因素分析用于确定男性和女性患者的因素，同时构建逻辑回归模型以生成比值比（OR），以预测与男性或女性ADNPS相关的风险因素。
在调整分析中，血脂异常（OR = 0.630，95%CI，0.431 - 0.992，P = 0.017）、甲状腺功能障碍（OR = 0.549，95%CI，0.377 - 0.798，P = 0.002）和脑梗死（OR = 0.684，95%CI，0.472 - 0.991，P = 0.0085）与男性ADNPS患者相关，而慢性心力衰竭（OR = 1.408，95%CI，0.953 - 2.079，P = 0.0085）与女性ADNPS患者相关。
我们的结果显示，女性ADNPS患者与心力衰竭相关，而男性患者与血脂异常和脑梗死相关。
