Shin Min Won, Kim Shin-Hye
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
Clin Exp Pediatr. 2025 Mar;68(3):199-222. doi: 10.3345/cep.2024.00556. Epub 2024 Nov 28.
The increasing prevalence of pediatric obesity has emerged as a significant public health concern. Among various contributing factors, exposure to endocrine-disrupting chemicals (EDCs) has gained recognition for its potential role. EDCs, including bisphenols, phthalates, per- and polyfluoroalkyl substances, polycyclic aromatic hydrocarbons, and organochlorines, disrupt hormonal regulation and metabolic processes, contributing to alterations in fat storage, appetite regulation, and insulin sensitivity. This study offers a comprehensive review of the current research linking EDC exposure to pediatric obesity by integrating the findings from experimental and epidemiological studies. It also addresses the complexities of interpreting this evidence in the context of public health, highlighting the urgent need for further research.
儿童肥胖患病率的不断上升已成为一个重大的公共卫生问题。在各种促成因素中，接触内分泌干扰化学物质（EDCs）因其潜在作用而受到关注。EDCs包括双酚类、邻苯二甲酸盐、全氟和多氟烷基物质、多环芳烃以及有机氯，它们会干扰激素调节和代谢过程，导致脂肪储存、食欲调节和胰岛素敏感性发生改变。本研究通过整合实验研究和流行病学研究的结果，对当前将EDC暴露与儿童肥胖联系起来的研究进行了全面综述。它还探讨了在公共卫生背景下解释这一证据的复杂性，强调了进一步研究的迫切需求。
