Mostafa Arab Eshagh Abadi, Emadi Rahmatollah, Shirali Danial, Khodaei Mohammad, Emadi Hosein, Saboori Abdollah
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Int J Biol Macromol. 2025 Jan;284(Pt 1):138097. doi: 10.1016/j.ijbiomac.2024.138097. Epub 2024 Nov 26.
The susceptibility of bone tissues to various factors such as ageing, accidents, and diseases has led to extensive tissue engineering research focusing on bone tissues. Hence, this research also aims to determine the optimal amount of Akermanite (AK) addition to the polylactic acid scaffold for bone tissue engineering applications, as well as the effects of surface modification on its properties. The Akermanite was synthesized using the sol-gel method. Then, composite scaffolds of polylactic acid, including 0, 10, 20, and 30 wt% AK, were printed via the fused deposition modelling (FDM) process. These scaffolds were labelled as PLA, 10 wt% AK, 20 wt% AK, and 30 wt% AK, respectively. The X-ray diffraction analysis confirmed the production of the AK high-purity phase. Cell viability tests on composite scaffolds confirmed non-toxicity, and cell adhesion improved with AK addition. Mechanical testing showed that the compressive strength of composite scaffolds increased by increasing the AK content of the composite. This study recommended the 20 wt% AK scaffold as the optimal composition for bone tissue engineering. The surface-modification of polylactic acid/AK composite scaffolds using sodium hydroxide showed that it can be suitable for advanced tissue structures and medical applications, contributing to advancements in tissue engineering and medical technology for improved bone treatments.
骨组织对衰老、事故和疾病等各种因素的易感性导致了针对骨组织的广泛组织工程研究。因此，本研究还旨在确定用于骨组织工程应用的聚乳酸支架中添加钙黄长石（AK）的最佳量，以及表面改性对其性能的影响。采用溶胶-凝胶法合成了钙黄长石。然后，通过熔融沉积建模（FDM）工艺打印了含0、10、20和30 wt%AK的聚乳酸复合支架。这些支架分别标记为PLA、10 wt%AK、20 wt%AK和30 wt%AK。X射线衍射分析证实了AK高纯度相的产生。对复合支架的细胞活力测试证实了其无毒性，并且随着AK的添加细胞粘附性得到改善。力学测试表明，复合支架的抗压强度随着复合材料中AK含量的增加而提高。本研究推荐20 wt%AK支架作为骨组织工程的最佳组成。使用氢氧化钠对聚乳酸/AK复合支架进行表面改性表明，它适用于先进的组织结构和医学应用，有助于推动组织工程和医疗技术的进步，以改善骨治疗。
