肥胖前期和肥胖（ob/ob）小鼠肝脏中分离出的细胞核与三碘甲状腺原氨酸的结合减少。

Decreased triiodothyronine binding to isolated nuclei from livers of preobese and obese (ob/ob) mice.

作者信息

Khan S G, Boyle P C, Lachance P A

出版信息

Proc Soc Exp Biol Med. 1986 May;182(1):84-7. doi: 10.3181/00379727-182-42313.

Abstract

L-Triiodothyronine (T3) binding to hepatic nuclei from (ob/ob) mice at different ages was examined and compared with that of lean controls. Results showed a significant reduction in T3 binding in liver nuclei of obese mice at all ages studied. The preobese mice at 2 weeks of age had 27.9% fewer receptor sites/mg DNA compared to lean controls, receptor concentration further decreased to 67.7% at 18 weeks of age. Data presented here demonstrates that the impaired triiodothyronine (T3) binding to hepatic nuclei present in older (ob/ob) obese mice is an antecedent to the obesity. This report also helps to explain the poor thermoregulation and low oxygen consumption present during the preobese phase of the postnatal development of these animals.

摘要

研究了不同年龄的（ob/ob）小鼠肝细胞核与L-三碘甲状腺原氨酸（T3）的结合情况，并与瘦素对照小鼠进行了比较。结果显示，在所有研究年龄的肥胖小鼠肝细胞核中，T3结合均显著减少。2周龄的肥胖前期小鼠每毫克DNA的受体位点比瘦素对照小鼠少27.9%，18周龄时受体浓度进一步降至67.7%。此处呈现的数据表明，老年（ob/ob）肥胖小鼠肝细胞核中三碘甲状腺原氨酸（T3）结合受损是肥胖的先兆。本报告还有助于解释这些动物出生后发育的肥胖前期阶段出现的体温调节不良和低氧消耗现象。