Ilich Jasminka Z, Pokimica Biljana, Ristić-Medić Danijela, Petrović Snjezana, Arsić Aleksandra, Vasiljević Nadja, Vučić Vesna, Kelly Owen J
Institute for Successful Longevity, Florida State University, Tallahassee, Florida 32306, United States.
Group for Nutritional Biochemistry and Dietology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade 11000, Serbia; Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade 11000, Serbia.
Ageing Res Rev. 2025 Jan;103:102601. doi: 10.1016/j.arr.2024.102601. Epub 2024 Nov 26.
This is the third review in our series examining the connection between osteosarcopenic adiposity/obesity (OSA/OSO) syndrome and health impairments. The objective here was to examine whether there is a causal and/or bidirectional relationship between OSA and some chronic diseases. The search (in PubMed, Scopus, and WoS), screened for articles from their inception to the end of February 2024. Of n=859 articles retrieved, eleven met the eligibility criteria (having all three body composition compartments measured-bone, muscle, adipose tissue and being conducted in adult humans with chronic disease). The selected articles included four assessing OSA and cancers, one each assessing OSA and HIV, Cushing's disease (CD), chronic kidney disease (CKD), pulmonary function, and two for alcohol abuse-caused liver disease, as well as one 6-year study showing the progression to OSA over time. There was a positive relationship between OSA and each of the chronic diseases, as well as a possible bidirectional relationship between OSA and cancers. The evidence linking OSA with HIV, CD, CKD, liver disease, and pulmonary function, was insufficient to derive firm conclusions about their causal/bidirectional relations. This review emphasizes the need for a multidisciplinary approach in the management and treatment of chronic diseases where body composition assessment should get full attention. To close the knowledge gap, more studies about the role of OSA in chronic diseases are needed.
这是我们系列综述中的第三篇，探讨骨肌少肌性肥胖（OSA/OSO）综合征与健康损害之间的联系。本文的目的是研究OSA与某些慢性疾病之间是否存在因果关系和/或双向关系。检索（在PubMed、Scopus和WoS中）筛选了从创刊到2024年2月底的文章。在检索到的n = 859篇文章中，有11篇符合纳入标准（测量了所有三个身体成分部分——骨骼、肌肉、脂肪组织，且研究对象为患有慢性疾病的成年人）。所选文章包括4篇评估OSA与癌症的，1篇评估OSA与HIV、库欣病（CD）、慢性肾脏病（CKD）、肺功能的，2篇评估酒精滥用所致肝病的，以及1篇为期6年的研究显示随时间进展为OSA的。OSA与每种慢性疾病之间均存在正相关关系，且OSA与癌症之间可能存在双向关系。将OSA与HIV、CD、CKD、肝病和肺功能联系起来的证据，不足以就它们的因果/双向关系得出确凿结论。本综述强调在慢性疾病的管理和治疗中需要采取多学科方法，其中身体成分评估应得到充分关注。为了填补知识空白，需要开展更多关于OSA在慢性疾病中作用的研究。
