Department of Internal Medicine, University of Chicago, Chicago, IL, USA.
Department of Internal Medicine, University of Chicago, Chicago, IL, USA.
Clin Liver Dis. 2025 Feb;29(1):1-15. doi: 10.1016/j.cld.2024.08.001. Epub 2024 Oct 28.
The epidemiology of hepatocellular carcinoma (HCC) has shifted significantly in the last 2 decades with non-viral etiologies such as metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease on the rise. Key factors include the global obesity epidemic and the resurgence of alcohol use disorder, both of which were exacerbated by the coronavirus disease 2019 pandemic. While these non-viral etiologies of HCC are becoming the leading cause in developed countries, the potential impact of immigration patterns on Hepatitis B virus epidemiology cannot be ignored. The risk of HCC remains significant in individuals with cirrhosis and viral hepatitis after curative treatments.
在过去的 20 年中，肝细胞癌（HCC）的流行病学发生了重大变化，非病毒性病因（如代谢功能障碍相关脂肪性肝病和酒精性肝病）的发病率上升。主要因素包括全球肥胖症的流行和酒精使用障碍的再次出现，而这两者都因 2019 年冠状病毒病大流行而加剧。虽然这些非病毒性 HCC 病因在发达国家已成为主要病因，但移民模式对乙型肝炎病毒流行病学的潜在影响不容忽视。在接受根治性治疗后，肝硬化和病毒性肝炎患者的 HCC 风险仍然很大。
