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使用纳米碳示踪剂改善结直肠癌微创根治术中的淋巴结检测。

Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer.

作者信息

Xie Bingkai, Lin Guihe, Wang Zhijian, Xu Dongbo, Chen Jianxun, Lin Shuangming

机构信息

Department of Gastrointestinal Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, Fujian Province, China.

Department of Colorectal Surgery, People's Hospital, Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350103, Fujian Province, China.

出版信息

Discov Oncol. 2024 Nov 28;15(1):720. doi: 10.1007/s12672-024-01582-0.

Abstract

To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer (CRC) and the application value of carbon nanoparticle tracing. A total of 120 patients with CRC who underwent minimally invasive radical surgery were included. They were divided into groups according to whether they were grouped by carbon nano-tracers, and the baseline data were matched by propensity score method. Univariate and multivariate methods were used to evaluate lymph nodes and positive lymph nodes after minimally invasive radical surgery. The number of detected independent factors. After propensity score matching, there were 37 patients in the tracer group and the non-tracer group; there was no significant difference in baseline data between the two groups; the number of positive lymph nodes detected in the tracer group was significantly higher than that in the non-tracer group. The results of univariate analysis showed that gender, lesion location, maximum tumor diameter, and whether to perform nanocarbon tracing were all related to the number of lymph nodes detected after minimally invasive radical surgery. Nanocarbon tracing was an independent influencing factor for the number of lymph nodes detected after minimally invasive radical surgery. Pathological type, T stage, histopathological grade, nerve invasion, and whether or not with cancer nodules were all related to the number of positive lymph nodes detected after minimally invasive radical surgery; multivariate analysis showed that T stage, pathological Histological grade, vascular invasion, and cancer nodules were all independent influencing factors for the number of positive lymph nodes detected after minimally invasive radical surgery. The number of lymph nodes detected in patients with CRC after minimally invasive radical surgery is closely related to the location of the lesion and whether carbon nanoparticle tracing is performed; those with T2-4 stage, histological grade 3-4, combined with vascular invasion and cancer nodules are more likely to Positive lymph nodes were detected.

摘要

探讨结直肠癌(CRC)患者微创根治术后淋巴结检出的影响因素及碳纳米颗粒示踪的应用价值。纳入120例行微创根治术的CRC患者。根据是否采用碳纳米示踪剂分组,采用倾向评分法匹配基线数据。采用单因素和多因素方法评估微创根治术后的淋巴结及阳性淋巴结情况。检测独立因素数量。倾向评分匹配后,示踪剂组和非示踪剂组各有37例患者;两组基线数据无显著差异;示踪剂组检测到的阳性淋巴结数量显著高于非示踪剂组。单因素分析结果显示,性别、病变部位、肿瘤最大直径以及是否进行纳米碳示踪均与微创根治术后淋巴结检出数量有关。纳米碳示踪是微创根治术后淋巴结检出数量的独立影响因素。病理类型、T分期、组织病理学分级、神经侵犯以及是否伴有癌结节均与微创根治术后阳性淋巴结检出数量有关;多因素分析显示,T分期、病理组织学分级、血管侵犯以及癌结节均是微创根治术后阳性淋巴结检出数量的独立影响因素。CRC患者微创根治术后淋巴结检出数量与病变部位及是否进行碳纳米颗粒示踪密切相关;T2-4期、组织学分级3-4级、合并血管侵犯及癌结节者更易检测到阳性淋巴结。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/889b/11604857/f68f6c9bd73e/12672_2024_1582_Fig1_HTML.jpg

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