Thornton S N
Physiol Behav. 1986;36(2):229-33. doi: 10.1016/0031-9384(86)90008-9.
The drinking responses of pigeons infused simultaneously IV (0.334 ml/min) and ICV (2 microliters/min) for 15 min with various osmotic solutions were observed during, and for 60 min after, the combined infusions. Drinking in response to IV infusion of 0.5 M NaCl or 1.0 M sucrose was unaffected by simultaneous ICV infusion of 0.15 M NaCl, enhanced by ICV 0.3 M NaCl, inhibited during the infusion of water ICV and attenuated by ICV infusion of 0.9 M sucrose. Drinking in response to IV infusion of 1.0 M NaCl or 1.5 M sucrose, two solutions that would have greatly increased CSF sodium concentration, was only slightly affected by simultaneous ICV infusions of NaCl, sucrose or water. These results show that drinking following IV administration of osmotic stimuli can be affected by ICV infusions that may have further increased or decreased CSF sodium concentration thereby suggesting that CSF sodium concentration may play a "permissive role" in osmotically induced drinking.
在静脉内（0.334毫升/分钟）和脑室内（2微升/分钟）同时输注各种渗透压溶液15分钟期间及输注后60分钟内，观察鸽子的饮水反应。静脉输注0.5 M氯化钠或1.0 M蔗糖时的饮水不受同时脑室内输注0.15 M氯化钠的影响，脑室内输注0.3 M氯化钠可增强饮水，脑室内输注水时饮水受到抑制，脑室内输注0.9 M蔗糖可使饮水减弱。静脉输注1.0 M氯化钠或1.5 M蔗糖（这两种溶液会大幅提高脑脊液钠浓度）时的饮水，仅受到同时脑室内输注氯化钠、蔗糖或水的轻微影响。这些结果表明，静脉注射渗透压刺激后的饮水可受到脑室内输注的影响，脑室内输注可能进一步升高或降低了脑脊液钠浓度，从而提示脑脊液钠浓度可能在渗透压诱导的饮水中起“允许作用”。
