Yadav Ekta, Neupane Netra Prasad, Otuechere Chiagoziem A, Yadav Jagat Pal, Bhat Mashooq A, Al-Omar Mohamed A, Yadav Pankajkumar, Verma Amita
Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA.
Chem Biodivers. 2025 Apr;22(4):e202401551. doi: 10.1002/cbdv.202401551. Epub 2024 Dec 18.
Quercetin, a natural flavonol, is reported to have significant antioxidant and anti-inflammatory activity, which further aids in its good wound-healing properties via acting on acute as well as chronic inflammatory phases. The current study is focused on understanding the potential of the green-synthesized iron and zinc oxide bimetallic (i.e., zinc ferrite) nanoparticles of quercetin (ZFQNP) on wound healing by an in vivo study model. Bimetallic quercetin nanoparticles were prepared by the co-precipitation method and characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), and dynamic light scattering (DLS) analyses. Synthesized ZFQNP was utilized to prepare the ointment for topical application, and wound-healing activity was evaluated by using the excisional wound method in Wistar rats. The binding affinity of quercetin was ascertained against various wound-healing protein targets by molecular docking. Characterization data confirmed the synthesis of bimetallic ZFQNP of an irregular shape. Molecular docking studies showed satisfactory binding potential of quercetin with selected molecular targets. The study results of various parameters corroborated the significant wound-healing properties of ZFQNP, possibly attributed to the promising binding potential of quercetin with vital wound-healing targets. The study demonstrated that the quercetin bimetallic nanoparticles could provide a promising wound-healing effect.
槲皮素是一种天然黄酮醇，据报道具有显著的抗氧化和抗炎活性，通过作用于急性和慢性炎症阶段，进一步有助于其良好的伤口愈合特性。当前的研究聚焦于通过体内研究模型，了解槲皮素的绿色合成铁和氧化锌双金属（即锌铁氧体）纳米颗粒（ZFQNP）在伤口愈合方面的潜力。双金属槲皮素纳米颗粒通过共沉淀法制备，并通过紫外可见光谱、扫描电子显微镜（SEM）和动态光散射（DLS）分析进行表征。合成的ZFQNP用于制备局部应用的软膏，并通过切除伤口法在Wistar大鼠中评估伤口愈合活性。通过分子对接确定槲皮素对各种伤口愈合蛋白靶点的结合亲和力。表征数据证实了不规则形状的双金属ZFQNP的合成。分子对接研究表明槲皮素与选定分子靶点具有令人满意的结合潜力。各种参数的研究结果证实了ZFQNP具有显著的伤口愈合特性，这可能归因于槲皮素与重要伤口愈合靶点有良好的结合潜力。该研究表明，槲皮素双金属纳米颗粒可提供有前景的伤口愈合效果。
