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Brain-derived neurotrophic factor plays with TRiC: focus on synaptic dysfunction in Huntington's disease.

作者信息

Gu Yingli, Sung Kijung, Wu Chengbiao

机构信息

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

出版信息

Neural Regen Res. 2025 Oct 1;20(10):2919-2920. doi: 10.4103/NRR.NRR-D-24-00679. Epub 2024 Sep 24.

DOI:10.4103/NRR.NRR-D-24-00679
PMID:39610103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11826460/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cb/11826460/723329338053/NRR-20-2919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cb/11826460/723329338053/NRR-20-2919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cb/11826460/723329338053/NRR-20-2919-g001.jpg

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Brain-derived neurotrophic factor plays with TRiC: focus on synaptic dysfunction in Huntington's disease.脑源性神经营养因子与TRiC相互作用：聚焦亨廷顿舞蹈病中的突触功能障碍
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2
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.脑源性神经营养因子和三构象维持蛋白样试剂挽救亨廷顿病小鼠模型皮质突触缺陷。
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3
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本文引用的文献

1
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease.脑源性神经营养因子和三构象维持蛋白样试剂挽救亨廷顿病小鼠模型皮质突触缺陷。
Neurobiol Dis. 2024 Jun 1;195:106502. doi: 10.1016/j.nbd.2024.106502. Epub 2024 Apr 10.
2
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons.低温电子断层扫描揭示亨廷顿病患者 iPSC 衍生和小鼠原代神经元中的细胞器表型。
Nat Commun. 2023 Feb 8;14(1):692. doi: 10.1038/s41467-023-36096-w.
3
Cortical and Striatal Circuits in Huntington's Disease.
亨廷顿舞蹈病中的皮质与纹状体回路
Front Neurosci. 2020 Feb 6;14:82. doi: 10.3389/fnins.2020.00082. eCollection 2020.
4
Cortical circuit alterations precede motor impairments in Huntington's disease mice.皮质电路改变先于亨廷顿病小鼠的运动障碍。
Sci Rep. 2019 Apr 29;9(1):6634. doi: 10.1038/s41598-019-43024-w.
5
Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease.亨廷顿病敲入小鼠模型皮质神经元中 BDNF 释放减少。
Sci Rep. 2018 Nov 19;8(1):16976. doi: 10.1038/s41598-018-34883-w.
6
Molecular insights into cortico-striatal miscommunications in Huntington's disease.亨廷顿病中海马-纹状体通讯障碍的分子机制研究
Curr Opin Neurobiol. 2018 Feb;48:79-89. doi: 10.1016/j.conb.2017.10.019. Epub 2017 Nov 7.
7
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.TRiC亚基增强脑源性神经营养因子的轴突运输并挽救亨廷顿舞蹈病中的纹状体萎缩。
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6.
8
The Biology of Huntingtin.亨廷顿蛋白的生物学。
Neuron. 2016 Mar 2;89(5):910-26. doi: 10.1016/j.neuron.2016.02.003.
9
BDNF and synaptic plasticity, cognitive function, and dysfunction.脑源性神经营养因子与突触可塑性、认知功能及功能障碍。
Handb Exp Pharmacol. 2014;220:223-50. doi: 10.1007/978-3-642-45106-5_9.
10
Brain-derived neurotrophic factor in neurodegenerative diseases.神经退行性疾病中的脑源性神经营养因子
Nat Rev Neurol. 2009 Jun;5(6):311-22. doi: 10.1038/nrneurol.2009.54.