Faculty of Medicine, Syrian Private University, Damascus, Syria.
Pulmonary and Critical Care Medicine, Department of Internal Medicine, Damascus University, Damascus, Syria.
J Int Med Res. 2024 Nov;52(11):3000605241299943. doi: 10.1177/03000605241299943.
In this multicenter retrospective study, we evaluated the prognostic role of blood eosinophil count on clinical outcomes in hospitalized patients with exacerbations of chronic obstructive pulmonary disease (COPD).
We included patients aged 20 to 90 years with a COPD diagnosis. Patients were divided into groups with blood eosinophil count ≤300 or >300 cells/μL and then further classified into 1-99, 100-300, or >300 cells/μL. We compared sociodemographic features and clinical outcomes between groups and identified risk factors associated with mortality in hospitalized patients with COPD and blood eosinophil count ≤300 cells/μL.
In total, 217 patients were included (82% men, average age 64.3±10.3 years). Patients with eosinophil counts ≤300 cells/μL had significantly longer hospital stays, more admissions to the intensive care unit (22.2% vs. 4.3%), and more frequent mechanical ventilation (21.6% vs. 4.3%) than those with eosinophil counts >300 cells/μL. Mortality only occurred in the group with ≤300 cells/μL; patients with COPD who had eosinophil counts >300 cells/μL had significantly better survival rates (17.0% vs. 0%).
High blood eosinophil counts at admission were associated with improved short-term outcomes. Our findings reveal the importance of considering eosinophil counts in clinical decision-making to manage hospitalized patients with COPD.
在这项多中心回顾性研究中，我们评估了血液嗜酸性粒细胞计数对慢性阻塞性肺疾病（COPD）加重住院患者临床结局的预后作用。
我们纳入了年龄在 20 至 90 岁之间、患有 COPD 的患者。患者被分为血液嗜酸性粒细胞计数≤300 或>300 细胞/μL 的组，然后进一步分为 1-99、100-300 或>300 细胞/μL。我们比较了各组之间的社会人口统计学特征和临床结局，并确定了血液嗜酸性粒细胞计数≤300 细胞/μL 的 COPD 住院患者与死亡率相关的危险因素。
共纳入 217 例患者（82%为男性，平均年龄 64.3±10.3 岁）。嗜酸性粒细胞计数≤300 细胞/μL 的患者住院时间明显更长，入住重症监护病房的比例更高（22.2% vs. 4.3%），需要机械通气的频率更高（21.6% vs. 4.3%）。嗜酸性粒细胞计数>300 细胞/μL 的患者死亡率仅发生在≤300 细胞/μL 组；嗜酸性粒细胞计数>300 细胞/μL 的 COPD 患者的生存率明显更高（17.0% vs. 0%）。
入院时的高血液嗜酸性粒细胞计数与改善短期结局相关。我们的研究结果揭示了在管理 COPD 住院患者时，考虑嗜酸性粒细胞计数在临床决策中的重要性。
