Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Braga, Portugal.
LaPMET Associate Laboratory, University of Minho, Braga, Portugal.
J Biomed Mater Res A. 2025 Jan;113(1):e37839. doi: 10.1002/jbm.a.37839.
Nanoparticle-laden contact lenses are a formidable strategy for ocular drug delivery. However, incorporating nanoparticles to achieve sustained drug release without affecting the contact lenses' properties remains a challenging task. In this work, daily and monthly replacement silicone-hydrogel contact lenses laden with bovine serum albumin/hyaluronic acid (BSA/HA) nanoparticles are presented. These nanoparticle-laden contact lenses enable the sustained release of 5-fluorouracil (5-FU) in mimetic physiological conditions. The nanoparticle-laden contact lenses display properties similar to neat contact lenses, including refractive index, water content, UV/visible transmittance and chemical structure. Noteworthy attributes include the BSA/HA nanoparticles' low polydispersity, negative surface charge and a hydrodynamic size of 210 nm, as well as the high nanoparticle loading efficiency ( 30%) of the contact lenses. Thereby, the BSA/HA nanoparticles are a promising strategy for developing nanoparticle-laden contact lenses for therapeutic applications, namely for sustained drug delivery.
载药纳米粒子隐形眼镜是眼部药物输送的一种有效策略。然而，将纳米粒子整合到隐形眼镜中以实现药物的持续释放而不影响隐形眼镜的性能仍然是一项具有挑战性的任务。在这项工作中，我们提出了每日和每月更换的负载牛血清白蛋白/透明质酸（BSA/HA）纳米粒子的硅水凝胶隐形眼镜。这些载药纳米粒子隐形眼镜能够在模拟生理条件下持续释放 5-氟尿嘧啶（5-FU）。载药纳米粒子隐形眼镜具有与纯隐形眼镜相似的性能，包括折射率、含水量、紫外/可见光透过率和化学结构。值得注意的是，BSA/HA 纳米粒子具有低多分散性、负表面电荷和约 210nm 的水动力学尺寸，以及隐形眼镜的高纳米粒子负载效率（约 30%）。因此，BSA/HA 纳米粒子是开发用于治疗应用的载药隐形眼镜的一种很有前途的策略，特别是用于持续药物输送。
