Taha Nadia, Daoud Hasan, Malik Tahira, Shettysowkoor Jeevith, Rahman Shafiq
Department of Plastic Surgery, Leeds Teaching Hospitals National Health Service (NHS) Trust, Leeds, GBR.
Department of Orthopaedics, Hull Royal Infirmary, Hull, GBR.
Cureus. 2024 Oct 28;16(10):e72542. doi: 10.7759/cureus.72542. eCollection 2024 Oct.
Low-level laser therapy (LLLT) is a non-invasive application of non-thermogenic light that is proven to promote tissue healing and alleviate pain. The authors aim to conduct the first meta-analysis, evaluating the effects of LLLT on wound healing and pain in skin wounds by comparing it to skin wounds not treated with LLLT. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed by searching the electronic databases. Eighteen randomised controlled trials that met the inclusion criteria were included in the study. Six hundred seventy skin wounds were analysed in the study. The primary outcome measures were the percentage reduction in wound size and the rate of complete wound healing. The secondary outcome measures included the visual analogue scale (VAS) for pain and the perineal pain score in episiotomy wounds. The percentage reduction of wound size in the LLLT group was significantly greater than that in the control group (95% confidence interval, CI, 13.93-37.70; p < 0.0001). In addition, the rate of wound healing was significantly greater in the LLLT group (95% CI, 2.32-16.70; p = 0.0003). LLLT has been shown to reduce pain, with the VAS scores for pain being significantly lower in the LLLT group after treatment (95% CI, -2.52 to -0.19; p = 0.02). The authors present the first meta-analysis within the literature showing the effects of LLLT on wound healing and pain in skin wounds. Higher quality trials are recommended to enhance the current evidence base.
低强度激光疗法（LLLT）是一种非侵入性的非产热光应用，已被证明可促进组织愈合并减轻疼痛。作者旨在进行首次荟萃分析，通过将LLLT与未接受LLLT治疗的皮肤伤口进行比较，评估其对皮肤伤口愈合和疼痛的影响。按照系统评价和荟萃分析的首选报告项目指南检索电子数据库。该研究纳入了18项符合纳入标准的随机对照试验。研究中分析了670个皮肤伤口。主要结局指标为伤口大小减少的百分比和完全伤口愈合率。次要结局指标包括疼痛视觉模拟量表（VAS）和会阴侧切伤口的会阴疼痛评分。LLLT组伤口大小减少的百分比显著高于对照组（95%置信区间，CI，13.93 - 37.70；p < 0.0001）。此外，LLLT组的伤口愈合率显著更高（95%CI，2.32 - 16.70；p = 0.0003）。LLLT已被证明可减轻疼痛，治疗后LLLT组的疼痛VAS评分显著更低（95%CI，-2.52至-0.19；p = 0.02）。作者在文献中呈现了首次荟萃分析，显示了LLLT对皮肤伤口愈合和疼痛的影响。建议进行更高质量的试验以加强当前的证据基础。
