Department of Neurobiology, Harbin Medical University, Harbin, China.
Department of Neurosurgery, Harbin Medical University, Harbin, China.
Front Immunol. 2024 Nov 14;15:1442694. doi: 10.3389/fimmu.2024.1442694. eCollection 2024.
Multiple sclerosis (MS) is a chronic, progressive autoimmune disease, with increasing attention on the role of B cells in its pathogenesis. Despite this growing interest, a comprehensive analysis of research trends and emerging foci on B cells in MS is currently lacking. In this research, we utilize a bibliometric approach to visualize and analyze research trends and focal points in this field, offering a valuable reference for future mechanistic studies in MS.
We retrieved bibliometric data from the Web of Science Core Collection (WOSCC) for articles published between 2014 and 2023. VOSviewer 1.6.18 and CiteSpace 5.7R3 were used for co-authorship, co-occurrence, and citation analyses to identify key researchers, institutions, countries, and emerging themes in B cell research related to MS.
The analysis examined 5,578 articles published in 1,041 journals by 5,337 institutions globally. The United States leads in publication output, with Amit Bar-Or identified as the most influential author, and as the top journal in the field. Research has increasingly focused on the complex role of B cells in MS, particularly their involvement in the central nervous system (CNS) and mechanisms of anti-B cell therapy. Recent trends point to a growing focus on meningeal inflammation, kinase inhibitors, and Epstein-Barr virus, signaling a shift in research priorities.
This bibliometric analysis highlights pivotal research trends, key contributors, and emerging areas of interest in B cell research in MS from 2013 to 2024. The findings underscore the growing recognition of the multifaceted role of B cells in MS pathogenesis, particularly their involvement in the CNS compartment and the potential of targeted therapies. The study identifies meningeal inflammation, Epstein-Barr virus infection, and kinase inhibitors as promising avenues for future research. The analyses driving the in-depth exploration of B cell mechanisms in MS and the development of novel diagnostic and therapeutic strategies provide researchers in the MS field with a comprehensive and objective perspective, serving as a valuable reference for accelerating the translation of basic research findings into clinical applications.
多发性硬化症（MS）是一种慢性、进行性自身免疫性疾病，人们越来越关注 B 细胞在其发病机制中的作用。尽管人们对此兴趣日益浓厚，但目前仍缺乏对 MS 中 B 细胞研究趋势和新兴焦点的全面分析。在这项研究中，我们采用文献计量学方法对该领域的研究趋势和焦点进行可视化和分析，为 MS 的未来机制研究提供了有价值的参考。
我们从 Web of Science 核心合集（WOSCC）中检索了 2014 年至 2023 年期间发表的文献的计量学数据。使用 VOSviewer 1.6.18 和 CiteSpace 5.7R3 进行共著分析、共现分析和引文分析，以确定与 MS 相关的 B 细胞研究中的关键研究人员、机构、国家和新兴主题。
该分析共检查了来自全球 5337 个机构的 1041 种期刊上发表的 5578 篇文章。美国在发表成果方面处于领先地位，Amit Bar-Or 被确定为最有影响力的作者，而《多发性硬化症杂志》是该领域的顶级期刊。研究越来越关注 B 细胞在 MS 中的复杂作用，特别是它们在中枢神经系统（CNS）中的作用以及抗 B 细胞治疗的机制。最近的趋势表明，人们越来越关注脑膜炎症、激酶抑制剂和 Epstein-Barr 病毒，表明研究重点正在发生转变。
这项文献计量学分析突出了 2013 年至 2024 年 MS 中 B 细胞研究的关键研究趋势、主要贡献者和新兴研究领域。研究结果强调了 B 细胞在 MS 发病机制中的多方面作用日益受到认可，特别是它们在中枢神经系统中的作用以及靶向治疗的潜力。研究确定脑膜炎症、Epstein-Barr 病毒感染和激酶抑制剂是未来研究的有希望的方向。这些分析推动了对 MS 中 B 细胞机制的深入探索以及新的诊断和治疗策略的发展，为 MS 领域的研究人员提供了全面和客观的视角，为加速基础研究成果向临床应用的转化提供了有价值的参考。
