Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Int J Mol Med. 2025 Feb;55(2). doi: 10.3892/ijmm.2024.5463. Epub 2024 Nov 29.
N6‑methyladenosine (mA) is one of the most universal, abundant and conserved types of internal post‑transcriptional modifications in eukaryotic RNA, and is involved in nuclear RNA export, RNA splicing, mRNA stability, gene expression, microRNA biogenesis and long non‑coding RNA metabolism. AlkB homologue 5 (ALKBH5) acts as a m6A demethylase to regulate a wide variety of biological processes closely associated with tumour progression, tumour metastasis, tumour immunity and tumour drug resistance. ALKBH5 serves a crucial role in human digestive system tumours, mainly through post‑transcriptional regulation of mA modification. The present review discusses progress in the study of the m6A demethylase ALKBH5 in gastrointestinal tract cancer, summarizes the potential molecular mechanisms of ALKBH5 dysregulation in gastrointestinal tract cancer, and discusses the significance of ALKBH5‑targeted therapy, which may provide novel ideas for future clinical prognosis prediction, biomarker identification and precise treatment.
N6-甲基腺苷（m6A）是真核 RNA 中最普遍、最丰富和最保守的内部转录后修饰类型之一，参与核 RNA 输出、RNA 剪接、mRNA 稳定性、基因表达、miRNA 生物发生和长非编码 RNA 代谢。 AlkB 同源物 5（ALKBH5）作为 m6A 去甲基酶，调节与肿瘤进展、肿瘤转移、肿瘤免疫和肿瘤耐药密切相关的广泛生物学过程。ALKBH5 在人类消化系统肿瘤中发挥着关键作用，主要通过 mA 修饰的转录后调控。本综述讨论了 m6A 去甲基酶 ALKBH5 在胃肠道癌中的研究进展，总结了 ALKBH5 在胃肠道癌中失调的潜在分子机制，并探讨了 ALKBH5 靶向治疗的意义，这可能为未来的临床预后预测、生物标志物识别和精准治疗提供新的思路。
