Delle Monache C, Delli Pizzi C, Di Giandomenico E, Nuzzo A
Radiol Med. 1986 Jan-Feb;72(1-2):22-5.
Three cases of primitive suprasellar germinomas are reported: the tumors show typical clinical signs (diabetes insipidus, visual disturbances and anterior pituitary dysfunctions), but CT findings are not so specific. It is very important to reach a correct diagnosis based on clinical and radiological findings, because of a very high radiosensibility of the tumor. The accuracy of preoperative diagnosis has been enhanced by CT in addition to conventional neuroradiological examinations. Due to the possible risk of meningeal spreading following biopsy, some authors prefer to avoid biopsy and to treat directly the patient by radiotherapy; a rapid reduction of the tumor size at the dose of 30 Gy suggests a possible germinoma.
报告了3例原发性鞍上生殖细胞瘤:这些肿瘤表现出典型的临床症状(尿崩症、视觉障碍和垂体前叶功能障碍),但CT表现并不那么具有特异性。由于该肿瘤对放疗高度敏感,基于临床和影像学表现做出正确诊断非常重要。除了传统的神经放射学检查外,CT提高了术前诊断的准确性。由于活检后可能存在脑膜播散的风险,一些作者倾向于避免活检,直接对患者进行放疗;30 Gy剂量下肿瘤大小迅速缩小提示可能为生殖细胞瘤。