Turpin G, Metzger J, Bataini J, de Gennes J L
Ann Endocrinol (Paris). 1979 Jul-Aug;40(4):371-84.
On the basis of 3 cases of hypothalamic tumours (glioma of the hypothalamus or of the stem of the pituitary, glioma of the hypothalamus or of the optic chiasma, pinealoblastoma), the authors emphasise: (1) the existence of a special endocrine "formula" since it often combines anterior pituitary insufficiency, diabetes insipidus and moderate hyperprolactinaemia; (2) the remarkable efficacy, in all 3 cases, of cobalt therapy, tumour regression becoming complete during the 6 to 10 months following the end of radiotherapy; (3) the post-radiotherapeutic endocrine complications, endocrine deficit becoming greater whilst the tumour disappeared; (4) the diagnostic possibilities and above all regular surveillance now made possible by tomodensitometry.
基于3例下丘脑肿瘤(下丘脑或垂体柄胶质瘤、下丘脑或视交叉胶质瘤、松果体母细胞瘤),作者强调:(1)存在一种特殊的内分泌“模式”,因为它常合并垂体前叶功能减退、尿崩症和中度高泌乳素血症;(2)在所有3例病例中钴治疗效果显著,放疗结束后6至10个月肿瘤完全消退;(3)放疗后的内分泌并发症,肿瘤消失时内分泌功能减退加重;(4)诊断可能性,尤其是现在通过计算机断层扫描能够进行定期监测。