Latini P, Checcaglini F, Maranzano E, Panizza B M, Aristei C, Raymondi C, Caprino G
Radiol Med. 1986 Jan-Feb;72(1-2):49-56.
From 1975 to 1982, among 138 patients affected by stage IB and IIA-B cervical carcinoma, 93 were treated with radiotherapy and surgery, while 45 were treated with radiotherapy alone. 137Cs applied with individual "moulages" was used for uterine-vaginal brachycurietherapy, while telecobalt therapy was used in external beam radiotherapy. Surgery consisted of either a classical Wertheim-Meigs procedure or a hysterosalpingo-oophorectomy with pelvic lymphadenectomy. Dosage methods for remote-loading curietherapy with 137Cs are discussed. Actuarial survival at 5 years in the 56 patients in stage IB was 90.2% +/- 3; in the 37 patients in stage IIA was 75% +/- 5; and in the 45 patients in stage IIB was 46.2% +/- 7.5. Average follow-up was 6.5 years, with a minimum of 3 years. Survival results in patients undergoing radiotherapy alone were not substantially different. Causes for therapeutic failure were pelvic relapse in 9.4% of the cases, distant metastases in 3.6% and relapse plus metastases in 8.6% of the cases. Severe complications were seen in 2.8% of the cases; mild complications in 8.6% of the cases.
1975年至1982年期间，138例患有IB期和IIA - B期宫颈癌的患者中，93例接受了放疗和手术治疗，而45例仅接受了放疗。采用137铯并结合个体化“模具”进行子宫 - 阴道近距离放射治疗，而外照射放疗采用钴远距离治疗。手术包括经典的韦特海姆 - 梅格斯手术或子宫输卵管卵巢切除术加盆腔淋巴结清扫术。讨论了137铯远距离加载近距离放射治疗的剂量方法。IB期56例患者的5年精算生存率为90.2%±3；IIA期37例患者为75%±5；IIB期45例患者为46.2%±7.5。平均随访时间为6.5年，最短为3年。仅接受放疗的患者的生存结果无显著差异。治疗失败的原因是9.4%的病例出现盆腔复发，3.6%出现远处转移，8.6%的病例复发加转移。2.8%的病例出现严重并发症；8.6%的病例出现轻度并发症。
