Prippenow G, Prippenow C, Nolte H
Reg Anaesth. 1986 Jan;9(1):26-30.
Nine volunteers received two intravenous regional anaesthetics in the right arm. The first anaesthetic consisted of an injection of 0.5% lignocaine (0.5 ml/kg body wt.), immediately followed by 0.9% NaCl (0.5 ml/kg body wt.). The second anaesthetic consisted of 0.25% lignocaine (1.0 ml/kg body wt.). Just prior to pressure release of the cuff and 30 s, 2, 5, 10, and 20 min afterward, venous blood samples were taken from the contralateral cubital vein in both groups. Lignocaine blood levels were determined by the fluorescence polarization method with the Abbott-TDx. As expected, in the first 2 min after cuff deflation, the blood levels were significantly lower in the first group. However, the peak levels did not differ significantly between groups (5-10 min). Therefore, one can expect slightly less toxicity using the combined injection technique. No significant systemic side effects of the drug were observed. On the basis of this investigation, 0.5% lignocaine (0.5 ml/kg body wt.) followed immediately by 0.9% NaCl (0.5 ml/kg body wt.) can be recommended for IV regional anaesthesia, as this seems to be less toxic than the diluted lignocaine that is usually used.
九名志愿者右臂接受了两次静脉区域麻醉。第一种麻醉剂包括注射0.5%利多卡因（0.5毫升/千克体重），随后立即注射0.9%氯化钠（0.5毫升/千克体重）。第二种麻醉剂为0.25%利多卡因（1.0毫升/千克体重）。在松开袖带前以及松开后30秒、2分钟、5分钟、10分钟和20分钟时，两组均从对侧肘静脉采集静脉血样。利多卡因血药浓度采用雅培TDx荧光偏振法测定。正如预期的那样，在松开袖带后的前2分钟内，第一组的血药浓度明显较低。然而，两组的峰值浓度没有显著差异（5至10分钟）。因此，可以预期联合注射技术的毒性略低。未观察到该药物明显的全身副作用。基于这项研究，0.5%利多卡因（0.5毫升/千克体重）后立即注射0.9%氯化钠（0.5毫升/千克体重）可推荐用于静脉区域麻醉，因为这似乎比通常使用的稀释利多卡因毒性更小。
