Department of Ophthalmology Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Medicine (Baltimore). 2024 Nov 29;103(48):e40666. doi: 10.1097/MD.0000000000040666.
Previous research has indicated a possible link between mobile phone usage and the incidence of glaucoma. This study employs a 2-sample Mendelian randomization (MR) analysis to examine the causal relationship between mobile phone use and glaucoma risk. We used single nucleotide polymorphisms (SNPs) from publicly accessible genome-wide association study (GWAS) datasets as instrumental variables (IVs). The primary analytical method was the inverse variance weighted (IVW) approach, with MR-Egger and weighted median analyses serving as complementary methods. Sensitivity was evaluated using Cochran's Q test and MR-Egger regression. The results demonstrate a causal effect of mobile phone usage on an increased risk of glaucoma (ORIVW = 1.358, 95% CI: 1.052-1.752, P = .019; ORMR-Egger = 1.882, 95% CI: 0.53-6.682, P = .337; ORWeighted median = 1.387, 95% CI: 1.012-1.900, P = .042; ORMR-PRESSO = 1.358, 95% CI: 1.052-1.752, P = .026). Sensitivity analyses confirmed the robustness and reliability of these findings. The study identifies mobile phone usage as a potentially modifiable risk factor for glaucoma, providing new avenues for exploring the specific mechanisms underlying these ocular disorders.
先前的研究表明，使用移动电话与青光眼的发病率之间可能存在关联。本研究采用双样本孟德尔随机化（MR）分析来检验使用移动电话与青光眼风险之间的因果关系。我们使用来自公开可得的全基因组关联研究（GWAS）数据集的单核苷酸多态性（SNP）作为工具变量（IV）。主要分析方法是逆方差加权（IVW）方法，MR-Egger 和加权中位数分析作为补充方法。使用 Cochran's Q 检验和 MR-Egger 回归评估敏感性。结果表明，移动电话的使用与青光眼风险的增加存在因果关系（ORIVW=1.358，95%CI：1.052-1.752，P=0.019；ORMR-Egger=1.882，95%CI：0.53-6.682，P=0.337；ORWeighted median=1.387，95%CI：1.012-1.900，P=0.042；ORMR-PRESSO=1.358，95%CI：1.052-1.752，P=0.026）。敏感性分析证实了这些发现的稳健性和可靠性。该研究确定了移动电话的使用是青光眼的一个潜在可改变的风险因素，为探索这些眼部疾病的具体机制提供了新的途径。
