Department for Global Public Health and Primary Care, Centre for International Health, Universitetet i Bergen, Bergen, Norway
Department of Research, Sykehuset Innlandet HF, Lillehammer, Norway.
BMJ Open. 2024 Nov 28;14(11):e085164. doi: 10.1136/bmjopen-2024-085164.
To provide details of a pooled data set that will be used to estimate absolute and relative mortality risks and other outcomes among children less than 59 months of age and the predictive performance of common risk exposures, both individually and in combination.
Children from birth to 5 years of age recruited at health facilities or community settings into 33 longitudinal observational or intervention studies in 17 low- and middle-income countries.
The data set includes 75 287 children with a median age of 3 months (IQR 1-12) at first measurement. In the pooled sample, 2805 (3.7%) of the study children died. Data on birth weight was recorded in 19 studies, and gestational age in 13 studies. Among these, 14% of the included children were reported as having low birth weight, and 14% had preterm birth. At first measurement, 33% of the children were stunted, 24% were wasted and 35% underweight. 13% and 7% of caregivers reported that their child had acute diarrhoea or acute lower respiratory tract infection before the study visit, respectively. The proportion of children reported as breastfed at any study visit decreased from 99% at age <6 months to 77% in the age group 12-23 months. Child characteristics differed considerably between studies in the community and healthcare settings. The median study period was 15 months (IQR 7.6-18.4 months).
Planned analyses will examine knowledge gaps with the aim of informing global guidelines and their derivatives such as clinical management tools and implementation guidance, and to inform future research agendas. We aim to estimate absolute mortality risks associated with child age, anthropometry, birth characteristics and feeding practices as planned by the WHO-Risk Stratification Working Group. In the future, other data sets may be added and further questions on survival and growth will be investigated.
提供一个综合数据集的详细信息，该数据集将用于估计 59 个月以下儿童的绝对和相对死亡率以及常见风险暴露的预测结果，包括单独和联合使用的情况。
来自 17 个中低收入国家的 33 项纵向观察性或干预性研究，在医疗机构或社区环境中招募的 0 至 5 岁儿童。
该数据集包含 75287 名儿童，中位数年龄为 3 个月（IQR 1-12），首次测量时。在汇总样本中，有 2805 名（3.7%）研究儿童死亡。19 项研究记录了出生体重数据，13 项研究记录了胎龄。其中，纳入的儿童中有 14%被报告为低出生体重，14%为早产。首次测量时，33%的儿童发育迟缓，24%消瘦，35%体重不足。13%和 7%的照顾者分别报告其孩子在研究访问前有急性腹泻或急性下呼吸道感染。在任何研究访问中报告母乳喂养的儿童比例从 6 个月以下的 99%下降到 12-23 个月的 77%。社区和医疗机构研究中的儿童特征差异很大。中位数研究期为 15 个月（IQR 7.6-18.4 个月）。
计划的分析将检查知识差距，旨在为全球指南及其衍生物（如临床管理工具和实施指南）提供信息，并为未来的研究议程提供信息。我们旨在根据世卫组织风险分层工作组的计划，估计与儿童年龄、人体测量学、出生特征和喂养方式相关的绝对死亡率风险。未来可能会添加其他数据集，并进一步研究生存和生长问题。
