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岛叶癫痫:功能、诊断方法和手术干预。

Insular Epilepsy: Functions, Diagnostic Approaches, and Surgical Interventions.

机构信息

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, 41390 Gothenburg, Sweden.

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

J Integr Neurosci. 2024 Nov 20;23(11):209. doi: 10.31083/j.jin2311209.

Abstract

Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects a significant portion of the global population, with drug-resistant epilepsy (DRE) presenting a major treatment challenge. Insular epilepsy, originating from this complex region, exhibits a broad range of symptoms, making diagnosis particularly difficult. Advanced imaging techniques and invasive procedures like stereoelectroencephalography (SEEG) are often crucial for accurately localizing the epileptogenic zone. Surgical resection remains the primary treatment for DRE, with recent advancements in microsurgical techniques and neuroimaging improving outcomes. Additionally, minimally invasive approaches like laser interstitial thermal therapy (LITT) and radiofrequency thermocoagulation (RFTC) offer promising alternatives.

摘要

癫痫是一种慢性神经系统疾病,其特征是反复发作的癫痫发作,影响了全球相当一部分人口,耐药性癫痫(DRE)是一个主要的治疗挑战。起源于这个复杂区域的岛叶癫痫表现出广泛的症状,使得诊断特别困难。先进的成像技术和立体脑电图(SEEG)等有创程序通常对于准确定位致痫区至关重要。手术切除仍然是 DRE 的主要治疗方法,最近微侵袭技术和神经影像学的进步改善了治疗效果。此外,激光间质热疗(LITT)和射频热凝(RFTC)等微创方法提供了有前途的替代方案。

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