Joshi Girish P, Kehlet Henrik, Lobo Dileep N
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.
Br J Anaesth. 2025 Feb;134(2):294-296. doi: 10.1016/j.bja.2024.10.018. Epub 2024 Nov 29.
Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX)-2-specific inhibitors provide significant analgesic and opioid-sparing benefits. However, these analgesics are commonly avoided owing to concerns of potential adverse effects. The evidence for NSAID-related adverse effects is conflicting and of poor quality, and these analgesics are safer than what has been implied. Thus, it is imperative that NSAIDs or COX-2-specific inhibitors are administered routinely unless there are well-founded contraindications.
非甾体抗炎药（NSAIDs）和环氧化酶（COX）-2特异性抑制剂具有显著的镇痛和节省阿片类药物的益处。然而，由于担心潜在的不良反应，这些镇痛药通常不被使用。关于NSAIDs相关不良反应的证据相互矛盾且质量不佳，而且这些镇痛药比人们所认为的更安全。因此，除非有充分的禁忌证，否则必须常规使用NSAIDs或COX-2特异性抑制剂。
