Department of Internal Medicine, Addiction Unit, Verona University Hospital, Verona, Italy.
Department of Neurosciences, University of Verona, Verona, Italy.
J Med Case Rep. 2024 Nov 29;18(1):578. doi: 10.1186/s13256-024-04938-w.
Cytisine is an alkaloid that is molecularly similar to nicotine and it is commonly used to treat smoking cessation. While it is considered a reasonably safe treatment option, cytisine intoxication in humans exhibits several adverse effects. These involve the gastrointestinal system (nausea, vomiting, diarrhea), the central nervous system (drowsiness, fatigue, delirium), and the motor system (muscle twitching and fasciculation, difficulties in walking).
We present a unique case report in which a Caucasian patient (an Italian 64-year-old woman) who was undergoing smoking cessation treatment with cytisine, and due to her misunderstanding of the therapeutic indications provided, took twice the recommended dose every day for 8 days, leading to an intake of 54 mg/dl of cytisine for 3 consecutive days. Notwithstanding the high dosage, the patient did not report any adverse reactions.
This confirms the safety of the drug, even at high doses, in patients aiming to quit smoking.
烟碱类似物昔尼克是一种与尼古丁在分子结构上相似的生物碱，常用于帮助戒烟。尽管昔尼克被认为是一种相对安全的治疗选择，但人体摄入昔尼克会出现多种不良反应。这些反应涉及胃肠道系统（恶心、呕吐、腹泻）、中枢神经系统（嗜睡、疲劳、意识混乱）和运动系统（肌肉抽搐和震颤、行走困难）。
我们报告了一个独特的病例，一名正在接受昔尼克戒烟治疗的高加索患者（一名意大利 64 岁女性），由于对提供的治疗指征存在误解，她每天服用两倍推荐剂量，持续了 8 天，导致连续 3 天摄入 54mg/dl 的昔尼克。尽管剂量很高，但患者没有报告任何不良反应。
这证实了即使在高剂量下，昔尼克对试图戒烟的患者也是安全的。
