Hillis W S, Jones C R, Been M, Campbell B C, Fulton W F
Scott Med J. 1986 Jan;31(1):25-9. doi: 10.1177/003693308603100106.
Acute myocardial infarction is associated with a high incidence of occluding coronary arterial thrombi. Thrombolytic therapy has been advocated to restore coronary artery blood flow and to reduce myocardial damage. Coronary arteriography and intracoronary thrombolytic therapy was administered to 61 patients admitted to a Coronary Care Unit within eight hours of symptoms. Successful reperfusion was obtained in 38 of 46 single vessel occlusions associated with a first coronary attack. Failure of reperfusion occurred in patients with two vessel occlusions or with cardiogenic shock. This study demonstrates the feasibility of applying this technique within a Coronary Care Unit with low capital and running costs, and suggests that its widespread application is possible even within the setting of a District General Hospital.
急性心肌梗死与冠状动脉血栓闭塞的高发生率相关。一直提倡采用溶栓疗法来恢复冠状动脉血流并减少心肌损伤。对61例在症状出现8小时内入住冠心病监护病房的患者进行了冠状动脉造影和冠状动脉内溶栓治疗。在46例与首次冠状动脉发作相关的单支血管闭塞患者中，有38例成功实现了再灌注。双支血管闭塞或心源性休克患者出现再灌注失败。这项研究证明了在冠心病监护病房内应用该技术的可行性，其资金和运营成本较低，并表明即使在地区综合医院的环境中也有可能广泛应用。
