Nakamura H, Masuda T, Yui N, Amano T, Naoto T
Department of Radiological Technology, Ibara City Hospital, 1186 Ibara-tyou, Ibara-city, Okayama, 715-0019, Japan.
Department of Radiological Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki-city, Okayama, 701-0193, Japan.
Radiography (Lond). 2025 Jan;31(1):220-223. doi: 10.1016/j.radi.2024.11.018. Epub 2024 Nov 30.
The abundance of epicardial adipose tissue (EAT) correlates with the extent and severity of coronary artery disease (CAD). If the quantity of EAT varies between diastole and systole during an ECG-synchronized volume scan, it can potentially affect the diagnostic accuracy of CAD. The aim of this study was to compare the EAT volume between the diastolic and systolic phases during an ECG-gated volume scan of patients with or without CAD.
In this study, 47 patients (11 with and 36 without CAD) underwent coronary computed tomography (CT) angiography between September 2022 and August 2023. All patients underwent a second-generation 320-row computed tomography (CT) scan with a retrospective ECG-triggered volume scan. The data volumes obtained at 5 % steps of the R-R interval were automatically analyzed on a Ziostation2 Plus workstation using a CT coronary artery analysis application. Myocardial fat components ranging from -160 to -70 in CT value were extracted to determine fat content. EAT volumes between R-R intervals were compared for 40 % diastolic and 75 % systolic phases in the scans of patients with and without CAD.
The median and interquartile range (IQR) of the EAT volumes were 130 (112-183) mL and 98 (67-129) mL for the groups with and without CAD, respectively, indicating a significant difference (p < 0.05). For the ECG-gated scan without CAD, the median and IQR of the EAT volumes were 98 (66-129) and 94 (68-134) mL in the diastolic and systolic phases (p = 0.82), respectively, and for CAD, 166 (129-191) and 158 (113-178) mL (p = 0.56), respectively. Thus, the differences in the EAT volume were not significant between diastolic and systolic phases (p > 0.05).
Differences in EAT volume between patients with and without CAD were significant. However, the EAT volume differences between the diastolic and systolic phases were not significant, irrespective of CAD, during the ECG-gated volume scans.
The diastolic and systolic cardiac phases did not significantly influence EAT volume measurements.
心外膜脂肪组织（EAT）的含量与冠状动脉疾病（CAD）的范围和严重程度相关。如果在心电图同步容积扫描期间，舒张期和收缩期之间的EAT量有所变化，那么它可能会影响CAD的诊断准确性。本研究的目的是比较CAD患者和非CAD患者在心电图门控容积扫描期间舒张期和收缩期之间的EAT容积。
在本研究中，47例患者（11例患有CAD，36例未患CAD）于2022年9月至2023年8月期间接受了冠状动脉计算机断层扫描（CT）血管造影。所有患者均接受了第二代320排计算机断层扫描（CT），并进行回顾性心电图触发容积扫描。在Ziostation2 Plus工作站上，使用CT冠状动脉分析应用程序自动分析在R-R间期5%步长下获得的数据量。提取CT值范围在-160至-70之间的心肌脂肪成分以确定脂肪含量。比较CAD患者和非CAD患者扫描中R-R间期之间舒张期40%和收缩期75%时的EAT容积。
患有CAD和未患CAD的组中，EAT容积的中位数和四分位间距（IQR）分别为130（112-183）mL和98（67-129）mL，表明存在显著差异（p<0.05）。对于无CAD的心电图门控扫描，舒张期和收缩期EAT容积的中位数和IQR分别为98（66-129）和94（68-134）mL（p=0.82），对于CAD患者，分别为166（129-191）和158（113-178）mL（p=0.56）。因此，舒张期和收缩期之间的EAT容积差异不显著（p>0.05）。
患有CAD和未患CAD的患者之间EAT容积差异显著。然而，在心电图门控容积扫描期间，无论是否患有CAD，舒张期和收缩期之间的EAT容积差异均不显著。
心脏舒张期和收缩期对EAT容积测量没有显著影响。
