活微生物摄入对糖尿病成人心血管疾病及死亡率的影响：一项全国性队列研究。

Impact of live microbe intake on cardiovascular disease and mortality in adults with diabetes: A nationwide cohort study.

作者信息

Li Jiaqi, Ye Jianan, Zhou Qin, Guo Keyu, Zhou Zhiguang

机构信息

National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

出版信息

Diabetes Res Clin Pract. 2025 Jan;219:111942. doi: 10.1016/j.diabres.2024.111942. Epub 2024 Nov 29.

DOI:10.1016/j.diabres.2024.111942

PMID:39615795

Abstract

OBJECTIVE

This study examines the association between dietary intake of live microbes (LM) and the risk of cardiovascular disease (CVD) and cardiovascular mortality in adults with diabetes.

METHODS

A retrospective cohort study was conducted using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2010, with follow-up mortality data through December 31, 2019. A total of 3,955 adults with diabetes were included. Dietary LM intake was categorized as low (LLM), medium (MLM), or high (HLM). Multivariate weighted logistic regression assessed the relationship between LM intake and CVD, and weighted Cox proportional hazards models were used to evaluate cardiovascular mortality.

RESULTS

Among the 3,955 participants, 1,064 had CVD. MLM consumers had a significantly lower risk of CVD (OR: 0.55; 95 % CI: 0.33, 0.92) compared to non-consumers, with no significant associations for LLM and HLM. During a median follow-up of 10.5 years, 432 cardiovascular deaths occurred. MLM intake was associated with a lower risk of cardiovascular mortality (HR: 0.65; 95 % CI: 0.49, 0.86).

CONCLUSION

Moderate consumption of dietary live microbes is associated with reduced CVD risk and cardiovascular mortality in adults with diabetes. These findings suggest potential cardiovascular benefits from including LM in the diet of diabetic patients.

摘要

目的

本研究探讨糖尿病成年人饮食中摄入活微生物（LM）与心血管疾病（CVD）风险及心血管死亡率之间的关联。

方法

利用2001年至2010年美国国家健康与营养检查调查（NHANES）数据进行回顾性队列研究，并获取截至2019年12月31日的随访死亡率数据。共纳入3955名糖尿病成年人。饮食中LM摄入量分为低（LLM）、中（MLM）或高（HLM）。多变量加权逻辑回归评估LM摄入量与CVD之间的关系，加权Cox比例风险模型用于评估心血管死亡率。

结果

在3955名参与者中，1064人患有CVD。与未摄入者相比，摄入MLM者患CVD风险显著降低（OR：0.55；95%CI：0.33，0.92），而LLM和HLM与CVD无显著关联。在中位随访10.5年期间，发生432例心血管死亡。摄入MLM与心血管死亡率较低相关（HR：0.65；95%CI：0.49，0.86）。