肿瘤浸润淋巴细胞在胃癌中的预后作用：一项系统评价和荟萃分析。

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.

作者信息

Cao Xiaoqing, Kang Yurou, Tai Ping, Zhang Pei, Lin Xin, Xu Fei, Nie Zhenlin, He Bangshun

机构信息

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China.

出版信息

Clin Res Hepatol Gastroenterol. 2025 Jan;49(1):102510. doi: 10.1016/j.clinre.2024.102510. Epub 2024 Nov 29.

DOI:10.1016/j.clinre.2024.102510

PMID:39615875

Abstract

BACKGROUND

To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.

METHODS

Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).

RESULTS

Higher CD4 TILs were correlated with favorable OS (HR=0.79, 95 %CI: 0.66-0.94, P = 0.009), the similar results were observed in tumor center and in infiltration margin. Higher CD8 TILs prolonged DFS (HR=0.69, 95 %CI: 0.51-0.95, P = 0.02) and OS (HR=0.96, 95 %CI: 0.94-0.99, P = 0.006); For OS, tumor center and infiltration margin groups showed positive results. Neither the overall analysis nor the subgroup analyses indicated that the level of FOXP3 TILs was associated with prognosis (DFS: HR=0.89, 95 %CI: 0.66-1.19, P = 0.42; OS: HR=0.98, 95 %CI: 0.85-1.13, P = 0.75). Pooled results revealed that higher CD3 TILs were correlated with favorable DFS (HR=0.69, 95 %CI: 0.56-0.84, P = 0.0003) but not OS (HR=1.00, 95 %CI: 0.99-1.01, P = 0.48).

CONCLUSIONS

High infiltrating CD3, CD4, CD8 T cells prolong survival, and FOXP3 subset is not related to prognosis in GC. For CD4 and CD8, positive correlations between the infiltration level and OS were present in tumor center and infiltration margin groups.

摘要

背景

分析肿瘤浸润淋巴细胞（TILs）亚型、浸润部位与胃癌（GC）患者预后之间的关系。

方法

通过系统检索和严格筛选获取符合条件的文章，收集研究信息并提取风险比（HR）、95%置信区间（CI），用于无病生存期（DFS）和总生存期（OS）的汇总分析。

结果

较高的CD4 TILs与较好的OS相关（HR=0.79，95%CI：0.66 - 0.94，P = 0.009），在肿瘤中心和浸润边缘观察到类似结果。较高的CD8 TILs延长了DFS（HR=0.69，95%CI：0.51 - 0.95，P = 0.02）和OS（HR=0.96，95%CI：0.94 - 0.99，P = 0.006）；对于OS，肿瘤中心和浸润边缘组显示出阳性结果。总体分析和亚组分析均未表明FOXP3 TILs水平与预后相关（DFS：HR=0.89，95%CI：0.66 - 1.19，P = 0.42；OS：HR=0.98，95%CI：0.85 - 1.13，P = 0.75）。汇总结果显示，较高的CD3 TILs与较好的DFS相关（HR=0.69，95%CI：0.56 - 0.84，P = 0.0003），但与OS无关（HR=1.00，95%CI：0.99 - 1.01，P = 0.48）。