Wang Xin, Zhang Pei, Suo JinShan, Li QingJian, Zhang Yu
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Eye (Lond). 2025 Feb;39(3):492-504. doi: 10.1038/s41433-024-03474-7. Epub 2024 Nov 30.
Endophthalmitis is a blinding disease that may lead to permanent vision loss. The diagnosis of endophthalmitis relies on clinical findings. It is crucial to identify causative microorganisms in time for subsequent treatment and saving vision. For a long time, cultures of vitreous and/or aqueous humours have been the gold standard for the diagnosis of endophthalmitis. The development of modern molecular diagnostic techniques has brought new opportunities for identifying pathogens rapidly and improving sensitivity. Intravitreal antibiotic injection has the become standard treatment option for infectious endophthalmitis in clinical practice, however, the role and timing of pars plana vitrectomy remains controversial. Moreover, the development of new drugs for intravitreal injection and posterior segment drug delivery systems is expected to achieve the transition from invasive to non-invasive management. Thus, endophthalmitis is an ophthalmic emergency and timely diagnosis and treatment are crucial for preserving vision.
眼内炎是一种可导致永久性视力丧失的致盲性疾病。眼内炎的诊断依赖于临床检查结果。及时识别致病微生物对于后续治疗和挽救视力至关重要。长期以来，玻璃体和/或房水培养一直是眼内炎诊断的金标准。现代分子诊断技术的发展为快速识别病原体和提高敏感性带来了新机遇。玻璃体内注射抗生素已成为临床实践中感染性眼内炎的标准治疗选择，然而，玻璃体切割术的作用和时机仍存在争议。此外，玻璃体内注射新药和眼后段给药系统的发展有望实现从侵入性治疗向非侵入性治疗的转变。因此，眼内炎是一种眼科急症，及时诊断和治疗对于保护视力至关重要。
