[小剂量-大作用？低剂量放射治疗（LDRT）在阿尔茨海默病（AD）中的应用] - Suppr

[Small dose-big effect? The use of low-dose radiation therapy (LDRT) in Alzheimer's disease (AD)].

作者信息

Fliedner Anna, Winterling Lena, Fietkau Rainer, Deloch Lisa

机构信息

Strahlenklinik, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.

Translationale Strahlenbiologie, Strahlenklinik, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.

出版信息

Strahlenther Onkol. 2025 Feb;201(2):204-206. doi: 10.1007/s00066-024-02336-1. Epub 2024 Nov 30.

DOI:10.1007/s00066-024-02336-1

PMID:39616284

Abstract

摘要

相似文献

[Small dose-big effect? The use of low-dose radiation therapy (LDRT) in Alzheimer's disease (AD)].[小剂量-大作用？低剂量放射治疗（LDRT）在阿尔茨海默病（AD）中的应用]

Strahlenther Onkol. 2025 Feb;201(2):204-206. doi: 10.1007/s00066-024-02336-1. Epub 2024 Nov 30.

Evaluation of Efficacy and Safety Using Low Dose Radiation Therapy with Alzheimer's Disease: A Protocol for Multicenter Phase II Clinical Trial.使用低剂量放射疗法治疗阿尔茨海默病的疗效和安全性评估：一项多中心 II 期临床试验方案。

J Alzheimers Dis. 2023;95(3):1263-1272. doi: 10.3233/JAD-230241.

The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study.低剂量放射治疗对轻至中度阿尔茨海默病痴呆患者的影响：一项试点研究的中期分析

Radiat Oncol J. 2023 Jun;41(2):89-97. doi: 10.3857/roj.2023.00052. Epub 2023 Jun 26.

Modulation of Neuroinflammation by Low-Dose Radiation Therapy in an Animal Model of Alzheimer's Disease.低剂量放射疗法在阿尔茨海默病动物模型中对神经炎症的调节作用。

Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):658-670. doi: 10.1016/j.ijrobp.2021.06.012. Epub 2021 Jun 16.

Radiation Therapy in Alzheimer's Disease: A Systematic Review.阿尔茨海默病的放射治疗：一项系统综述

Int J Radiat Oncol Biol Phys. 2024 May 1;119(1):23-41. doi: 10.1016/j.ijrobp.2023.11.044. Epub 2023 Nov 30.

Low-Dose Radiation Therapy (LDRT) against Cancer and Inflammatory or Degenerative Diseases: Three Parallel Stories with a Common Molecular Mechanism Involving the Nucleoshuttling of the ATM Protein?低剂量放射疗法（LDRT）对抗癌症以及炎症性或退行性疾病：三个平行的故事，有着涉及 ATM 蛋白核穿梭的共同分子机制？

Cancers (Basel). 2023 Feb 26;15(5):1482. doi: 10.3390/cancers15051482.

Preventive effects of low-dose radiation and hypofractionated radiation plus anti-programmed cell death protein 1 on lung metastasis in breast cancer.低剂量辐射与低分割辐射联合抗程序性细胞死亡蛋白1对乳腺癌肺转移的预防作用

Oncol Res. 2025 Feb 28;33(3):687-694. doi: 10.32604/or.2024.052133. eCollection 2025.

Effect of Low-Dose Radiation Therapy on Abscopal Responses to Hypofractionated Radiation Therapy and Anti-PD1 in Mice and Patients With Non-Small Cell Lung Cancer.低剂量放射治疗对小鼠和非小细胞肺癌患者中低分割放射治疗及抗程序性死亡蛋白1的远隔效应的影响

Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):212-224. doi: 10.1016/j.ijrobp.2020.05.002. Epub 2020 May 15.

The Use of Low-Dose Radiation Therapy in Osteoarthritis: A Review.低剂量辐射疗法在骨关节炎中的应用：综述。

Int J Radiat Oncol Biol Phys. 2022 Oct 1;114(2):203-220. doi: 10.1016/j.ijrobp.2022.04.029. Epub 2022 Apr 30.

Effectiveness of low-dose radiation therapy to improve mortality of COVID-19.低剂量辐射疗法对改善 COVID-19 死亡率的有效性。

J Cancer Res Clin Oncol. 2021 Sep;147(9):2621-2624. doi: 10.1007/s00432-021-03707-2. Epub 2021 Jul 5.

本文引用的文献

J Alzheimers Dis. 2023;95(3):1263-1272. doi: 10.3233/JAD-230241.

Low-Dose Whole Brain Radiation Therapy for Alzheimer's Dementia: Results From a Pilot Trial in Humans.低剂量全脑放射治疗阿尔茨海默病：一项在人体中的初步试验结果。

Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):87-95. doi: 10.1016/j.ijrobp.2023.03.044. Epub 2023 Mar 18.

Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects-challenges for future studies.低剂量放射治疗骨关节炎：从生物学发现到临床效果——未来研究的挑战。

Strahlenther Onkol. 2023 Dec;199(12):1164-1172. doi: 10.1007/s00066-022-02038-6. Epub 2023 Jan 5.

ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose-results after 3 months' follow-up.ArthroRad 试验：多中心前瞻性随机单盲试验，研究低剂量放射治疗对疼痛性骨关节炎的疗效，结果取决于 3 个月随访后的剂量。

Strahlenther Onkol. 2022 Apr;198(4):370-377. doi: 10.1007/s00066-021-01866-2. Epub 2021 Nov 1.

Modulation of Neuroinflammation by Low-Dose Radiation Therapy in an Animal Model of Alzheimer's Disease.低剂量放射疗法在阿尔茨海默病动物模型中对神经炎症的调节作用。

Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):658-670. doi: 10.1016/j.ijrobp.2021.06.012. Epub 2021 Jun 16.

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?阿尔茨海默病中的神经炎症和小胶质细胞激活：我们的路在何方？

Nat Rev Neurol. 2021 Mar;17(3):157-172. doi: 10.1038/s41582-020-00435-y. Epub 2020 Dec 14.

Cranial irradiation significantly reduces beta amyloid plaques in the brain and improves cognition in a murine model of Alzheimer's Disease (AD).在阿尔茨海默病（AD）小鼠模型中，颅脑照射可显著减少大脑中的β淀粉样蛋白斑块并改善认知功能。

Radiother Oncol. 2016 Jan;118(1):43-51. doi: 10.1016/j.radonc.2015.10.019. Epub 2015 Nov 23.

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[Small dose-big effect? The use of low-dose radiation therapy (LDRT) in Alzheimer's disease (AD)].

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