Yokomichi Hiroshi, Mochizuki Mie, Suzuki Shigeru, Ito Yoshiya, Hotsubo Tomoyuki, Matsuura Nobuo
Department of Epidemiology and Environmental Medicine, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409-3898, Japan.
Department of Paediatrics, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan; Department of Paediatrics, NHO Kofu National Hospital, 11-35 Tenjincho, Kofu, Yamanashi, Japan.
J Diabetes Complications. 2025 Jan;39(1):108922. doi: 10.1016/j.jdiacomp.2024.108922. Epub 2024 Nov 28.
To compare the incidence of end-stage renal disease (ESRD) between slowly progressive type 1 diabetes and acute-onset type 1 diabetes.
This cohort study enrolled all 521 patients with childhood-onset type 1 diabetes with the year of onset from 1959 to 1996 in Hokkaido Prefecture, Japan. We calculated the ESRD incidence rate per 100,000 person-years by sex, onset year, onset age, and type 1 diabetes subtype (slowly progressive or acute-onset). We also constructed a Kaplan-Meier curve for ESRD by these risk factors.
The data of 391 patients were gathered, among whom 66 developed ESRD. The ESRD incidence rate per 100,000 person-years was 525 among all patients; 538 and 503 among women (n = 235) and men (n = 156); 893, 413, and 225 for onset year of 1959-1979 (n = 107), 1980-1989 (n = 201), and 1990-1996 (n = 83); 420 and 715 for onset before (n = 243) and after (n = 148) puberty; and 1388 and 432 for the slowly progressive (n = 41) and acute-onset (n = 350) subtypes, respectively. The Kaplan-Meier curve also indicated a significantly higher incidence of ESRD in slowly progressive than in acute-onset type 1 diabetes.
The incidence of ESRD was higher in slowly progressive than acute-onset type 1 diabetes.
比较缓慢进展型1型糖尿病和急性起病型1型糖尿病终末期肾病（ESRD）的发病率。
这项队列研究纳入了日本北海道地区1959年至1996年发病的所有521例儿童期起病的1型糖尿病患者。我们按性别、发病年份、发病年龄和1型糖尿病亚型（缓慢进展型或急性起病型）计算了每10万人年的ESRD发病率。我们还根据这些危险因素构建了ESRD的Kaplan-Meier曲线。
收集了391例患者的数据，其中66例发生了ESRD。所有患者每10万人年的ESRD发病率为525；女性（n = 235）和男性（n = 156）分别为538和503；1959 - 1979年发病（n = 107）、1980 - 1989年发病（n = 201）和1990 - 1996年发病（n = 83）的发病率分别为893、413和225；青春期前（n = 243）和青春期后（n = 148）发病的发病率分别为420和715；缓慢进展型（n = 41）和急性起病型（n = 350）亚型的发病率分别为1388和432。Kaplan-Meier曲线也表明，缓慢进展型1型糖尿病的ESRD发病率显著高于急性起病型。
缓慢进展型1型糖尿病的ESRD发病率高于急性起病型1型糖尿病。
