Kopecka Katerina, Herman Michal, Michalek Jaroslav, Zapletalova Jana, Hermanova Marketa, Liptakova Priska, Hendrych Michal, Mozola Michal, Pink Richard
Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Oral Dis. 2025 Jul;31(7):2119-2128. doi: 10.1111/odi.15215. Epub 2024 Dec 1.
Tumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
The study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.
Significant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.
The ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.
肿瘤芽生被认为是口腔鳞状细胞癌（OSCC）的一个有价值的预后因素，但缺乏标准化的评分系统。本研究使用国际肿瘤芽生共识会议（ITBCC）2016推荐的评分系统评估OSCC中的肿瘤芽生。
本研究纳入了114例接受手术切除的OSCC患者。根据ITBCC标准评估肿瘤芽生，并分为三类（低、中、高肿瘤芽生）。研究肿瘤芽生与临床病理参数之间的关联，并采用Kaplan-Meier法进行生存率分析。通过Cox回归分析评估肿瘤芽生的预后价值。
发现肿瘤芽生与包括淋巴结转移、分级、分期、神经周围和脉管侵犯以及局部复发在内的临床病理参数存在显著相关性。中、高肿瘤芽生与较差的无病生存率显著且独立相关。高肿瘤芽生被确定为疾病特异性生存和总生存的独立预后因素。
ITBCC评分系统是一种评估OSCC中肿瘤芽生的简单、可行且可重复的方法。根据ITBCC标准，肿瘤芽生在接受手术切除的OSCC中显示出其预后价值，应考虑将其纳入组织病理学报告指南。
