Gupta Shruti, Sharma Deepti, Hooda Anita, Kamboj Mala
Department of Oral Anatomy, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India.
J Oral Pathol Med. 2025 Jan;54(1):3-11. doi: 10.1111/jop.13596. Epub 2024 Dec 1.
An altered blood lipid profile has been considered as a diagnostic and/or prognostic marker for cancer. Since oral cancer is usually preceded by oral potentially malignant disorders (OPMDs) and share common etiopathogenesis, thus researchers have tried to explore the role of blood lipid profile as a marker for OPMDs; however, no consensus has been made regarding the utilization of serum lipid profile as a biomarker for oral submucous fibrosis (OSMF). Thus, the present article aimed to validate serum lipid profile as a biomarker for OSMF.
PubMed, Scopus, Google Scholar and Clinical key databases were searched for relevant articles. Thirty-six studies that met the eligibility criteria were included for qualitative review, however, out of these, 27 studies with specific data for OSMF and the control group were included in the meta-analysis.
A significant reduction in very low-density lipoprotein (p = 0.042), low density lipoprotein (p = 0.006), high density lipoprotein (p = 0.020), triglyceride (p = 0.049) and total cholesterol (p = 0.009) levels in blood were observed in OSMF patients in comparison to healthy controls whereas no significant difference was seen in contrast to oral squamous cell carcinoma patients.
Although a significant alteration was observed in lipid levels in OSMF patients, considerable heterogeneity in all the studied parameters implies that blood lipid profile could not be used as a reliable biomarker for OSMF and require further investigation.
血脂谱改变被认为是癌症的诊断和/或预后标志物。由于口腔癌通常先于口腔潜在恶性疾病（OPMDs）出现，且二者具有共同的病因发病机制，因此研究人员试图探索血脂谱作为OPMDs标志物的作用；然而，关于将血清脂质谱用作口腔黏膜下纤维化（OSMF）生物标志物的问题尚未达成共识。因此，本文旨在验证血清脂质谱作为OSMF生物标志物的有效性。
检索了PubMed、Scopus、谷歌学术和Clinical key数据库中的相关文章。纳入36项符合纳入标准的研究进行定性综述，然而，其中27项具有OSMF和对照组具体数据的研究被纳入荟萃分析。
与健康对照组相比，OSMF患者血液中极低密度脂蛋白（p = 0.042）、低密度脂蛋白（p = 0.006）、高密度脂蛋白（p = 0.020）、甘油三酯（p = 0.049）和总胆固醇（p = 0.009）水平显著降低，而与口腔鳞状细胞癌患者相比无显著差异。
尽管OSMF患者的血脂水平有显著改变，但所有研究参数中存在相当大的异质性，这意味着血脂谱不能用作OSMF的可靠生物标志物，需要进一步研究。
