Pourali Ghazaleh, Toriola Adetunji T
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
Cancer Epidemiol Biomarkers Prev. 2024 Dec 2;33(12):1541-1543. doi: 10.1158/1055-9965.EPI-24-1271.
This commentary discusses the importance of adiposity and lifecourse growth with mammographic breast density (MBD) in non-Hispanic Black (NHB) women. Although high MBD is a well-established risk factor for breast cancer, the determinants of MBD in NHB women remain understudied. Although adiposity at the time of mammography is most strongly associated with MBD, adiposity as early as ages 10 and 18 years is also independently associated with MBD. The commentary emphasizes the need for future research to identify biological mechanisms underlying the associations of adulthood adiposity and lifecourse growth with MBD in NHB women and how these can be translated to breast cancer prevention. Additionally, it highlights the need for more studies looking at lifecourse growth and microscopic breast tissue characteristics such as terminal duct lobular unit involution and epithelial-to-stromal proportions. See related article by Bigham et al., p. 1640.
这篇评论文章探讨了非西班牙裔黑人（NHB）女性中肥胖及生命历程中的生长情况与乳腺钼靶密度（MBD）的重要性。尽管高MBD是乳腺癌公认的风险因素，但NHB女性中MBD的决定因素仍未得到充分研究。虽然乳腺钼靶检查时的肥胖与MBD关联最为紧密，但早在10岁和18岁时的肥胖也与MBD独立相关。该评论强调，未来研究需要确定成年期肥胖和生命历程中的生长与NHB女性MBD之间关联的潜在生物学机制，以及如何将这些机制转化为乳腺癌预防措施。此外，它还强调需要开展更多研究，关注生命历程中的生长以及微观乳腺组织特征，如终末导管小叶单位退化和上皮与基质比例。见比格姆等人的相关文章，第1640页。
