精准肿瘤学：2024年回顾

Precision Oncology: 2024 in Review.

作者信息

Repetto Matteo, Fernandez Nicole, Drilon Alexander, Chakravarty Debyani

机构信息

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

出版信息

Cancer Discov. 2024 Dec 2;14(12):2332-2345. doi: 10.1158/2159-8290.CD-24-1476.

DOI:10.1158/2159-8290.CD-24-1476

PMID:39618285

Abstract

This article discusses the specific advances made in precision oncology in 2024. We comment on the evolving nature of predictive molecular events used to select patients who will most benefit clinically from treatment. We also discuss advances in the development of strategic treatment regimens for combination therapies, rational drug design of small-molecule inhibitors, and structurally informed drug repurposing.

摘要

本文讨论了2024年精准肿瘤学取得的具体进展。我们对用于选择最能从治疗中临床获益的患者的预测性分子事件的不断演变的性质进行了评论。我们还讨论了联合治疗策略性治疗方案的开发进展、小分子抑制剂的合理药物设计以及基于结构的药物重新利用。