Cao Weihua, Jiang Tingting, Deng Wen, Wang Shiyu, Li Xinxin, Zhang Ziyu, Zhang Lu, Lu Yao, Chang Min, Liu Ruyu, Wu Shuling, Shen Ge, Gao Yuanjiao, Hao Hongxiao, Chen Xiaoxue, Hu Leiping, Xu Mengjiao, Yi Wei, Xie Yao, Li Minghui
Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Department of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Front Med (Lausanne). 2024 Nov 15;11:1384927. doi: 10.3389/fmed.2024.1384927. eCollection 2024.
To explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).
Data from all MASLD patients, diagnosed by liver biopsy, were enrolled and divided into MASLD alone group and MASLD with MS group. They were subdivided into hyperuricemia group and normal SU group to find correlation between SU/IR and MASLD in patients with MS and independent risk factors for MASLD.
Data from 539 MASLD patients were analyzed. Body mass index (BMI) ( = 0.000), waist circumference (WC) ( = 0.004), and low-density lipoprotein (LDL) ( = 0.000) were dramatically higher in MASLD with MS group than those with MASLD alone; MASLD with MS patients had significantly more family history of diabetes ( = 0.000) and hypertension ( = 0.000) than patients with MASLD alone. Height ( = 0.000), weight ( = 0.000), BMI ( = 0.000) and WC ( = 0.001), and LDL ( = 0.007) were dramatically higher in hyperuricemia patients than those with normal SU. SU was inversely associated with age ( = 0.000) and high-density lipoprotein (HDL) ( = 0.003), and positively correlated with weight ( = 0.000), BMI ( = 0.000) and WC ( = 0.000), TG ( = 0.000), and LDL ( = 0.000). Logistic Regression analysis showed that age ( = 0.031), TG ( = 0.002), LDL ( = 0.010), HbA1c ( = 0.026), and family history of hypertension ( = 0.000) may be independent risk factors for MASLD in patient with MS.
Insulin resistance (IR) in MASLD patients with MS, but not higher SU levels, has closer correlation with the occurrence of MASLD in patients with family history of hypertension and diabetes having higher BMI, LDL, HbA1c.
探讨代谢综合征（MS）患者血清尿酸（SU）水平或胰岛素抵抗（IR）与代谢功能障碍相关脂肪性肝病（MASLD）之间的相关性。
纳入经肝活检确诊的所有MASLD患者的数据，并分为单纯MASLD组和合并MS的MASLD组。将其进一步细分为高尿酸血症组和SU正常组，以探讨MS患者中SU/IR与MASLD之间的相关性以及MASLD的独立危险因素。
分析了539例MASLD患者的数据。合并MS的MASLD组的体重指数（BMI）（P = 0.000）、腰围（WC）（P = 0.004）和低密度脂蛋白（LDL）（P = 0.000）显著高于单纯MASLD组；合并MS的MASLD患者的糖尿病家族史（P = 0.000）和高血压家族史（P = 0.000）显著多于单纯MASLD患者。高尿酸血症患者的身高（P = 0.000）、体重（P = 0.000）、BMI（P = 0.000）、WC（P = 0.001）和LDL（P = 0.007）显著高于SU正常患者。SU与年龄（P = 0.000）和高密度脂蛋白（HDL）（P = 0.003）呈负相关，与体重（P = 0.000）、BMI（P = 0.000）、WC（P = 0.000）、甘油三酯（TG）（P = 0.000）和LDL（P = 0.000）呈正相关。Logistic回归分析显示，年龄（P = 0.031）、TG（P = 0.002）、LDL（P = 0.010）、糖化血红蛋白（HbA1c）（P = 0.026）和高血压家族史（P = 0.000）可能是MS患者发生MASLD的独立危险因素。
合并MS的MASLD患者中的胰岛素抵抗（IR）而非较高的SU水平，与有高血压和糖尿病家族史、BMI、LDL、HbA1c较高的患者发生MASLD的相关性更密切。
