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Pegylated Interferon Combined With Low-Dose Total Skin Electron Beam Therapy for Advanced Stage Mycosis Fungoides: Two Case Reports and Literature Review.

作者信息

Elsayad Khaled, Stadler Rudolf, Eich Hans Theodor

机构信息

Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.

Department of Radiation Oncology, UKGM Marburg, Marburg, Germany.

出版信息

Adv Radiat Oncol. 2024 Oct 28;10(1):101663. doi: 10.1016/j.adro.2024.101663. eCollection 2025 Jan.

DOI:10.1016/j.adro.2024.101663
PMID:39619150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11605184/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/cf7c4b8435e0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/1aa9efce2513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/257806eb1d9c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/cf7c4b8435e0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/1aa9efce2513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/257806eb1d9c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1371/11605184/cf7c4b8435e0/gr3.jpg

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1
Pegylated Interferon Combined With Low-Dose Total Skin Electron Beam Therapy for Advanced Stage Mycosis Fungoides: Two Case Reports and Literature Review.聚乙二醇化干扰素联合低剂量全身电子束治疗晚期蕈样肉芽肿：两例报告及文献综述
Adv Radiat Oncol. 2024 Oct 28;10(1):101663. doi: 10.1016/j.adro.2024.101663. eCollection 2025 Jan.
2
Combined total body X-ray irradiation and total skin electron beam radiotherapy with an improved technique for mycosis fungoides.联合全身X线照射和全身皮肤电子束放疗，并采用改良技术治疗蕈样肉芽肿。
Int J Radiat Oncol Biol Phys. 1989 Aug;17(2):427-32. doi: 10.1016/0360-3016(89)90461-6.
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A prospective, open-label study of low-dose total skin electron beam therapy in mycosis fungoides.蕈样肉芽肿低剂量全身皮肤电子束治疗的前瞻性开放标签研究。
Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1204-7. doi: 10.1016/j.ijrobp.2007.11.039. Epub 2008 Jan 22.
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[Long term results of total skin electron beam therapy (TSEBT) in the treatment of mycosis fungoides].[全身皮肤电子束治疗蕈样肉芽肿的长期疗效]
Hautarzt. 2003 Mar;54(3):256-64. doi: 10.1007/s00105-002-0419-8. Epub 2003 Jan 11.
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Short-term efficacy and safety of total skin electron beam therapy in mycosis fungoides: Systematic review and meta-analysis.蕈样肉芽肿患者行全身电子束照射的短期疗效和安全性：系统评价和荟萃分析。
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Radiotherapy of advanced mycosis fungoides: indications and results of total skin electron beam and photon beam irradiation.晚期蕈样肉芽肿的放射治疗：全身皮肤电子束和光子束照射的适应症及结果
Radiother Oncol. 2000 Jan;54(1):73-8. doi: 10.1016/s0167-8140(99)00162-0.
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Combination of low-dose total skin electron beam therapy and subsequent localized skin electron beam therapy as a therapeutic option for advanced-stage mycosis fungoides.低剂量全身电子束治疗联合后续局部电子束治疗作为晚期蕈样肉芽肿的治疗选择。
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Multiple courses of high-dose total skin electron beam therapy in the management of mycosis fungoides.多疗程大剂量全身皮肤电子束疗法在蕈样肉芽肿治疗中的应用
Int J Radiat Oncol Biol Phys. 1995 Jul 30;32(5):1445-9. doi: 10.1016/0360-3016(94)00590-H.
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Interventions for mycosis fungoides.蕈样肉芽肿的干预措施。
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Bone marrow suppression as a complication of total skin helical tomotherapy in the treatment of mycosis fungoides.骨髓抑制作为蕈样肉芽肿治疗中全身螺旋断层放疗的一种并发症。
Radiat Oncol. 2018 Apr 13;13(1):67. doi: 10.1186/s13014-018-1013-2.

本文引用的文献

1
Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group.皮肤淋巴瘤的放射治疗：EORTC 皮肤淋巴瘤肿瘤学组的建议。
Eur J Cancer. 2024 Nov;212:115064. doi: 10.1016/j.ejca.2024.115064. Epub 2024 Oct 8.
2
Pegylated interferon-α2a in cutaneous T-cell lymphoma - a multicenter retrospective data analysis with 70 patients.聚乙二醇干扰素-α2a 在皮肤 T 细胞淋巴瘤中的应用 - 一项 70 例患者的多中心回顾性数据分析。
J Dtsch Dermatol Ges. 2024 Nov;22(11):1489-1497. doi: 10.1111/ddg.15511. Epub 2024 Oct 2.
3
Real-world study of pegylated interferon α-2a to treat mycosis fungoides/Sézary syndrome using time to next treatment as a measure of clinical benefit: an EORTC CLTG study.
采用下一次治疗时间作为临床获益的衡量指标，对聚乙二醇干扰素 α-2a 治疗蕈样肉芽肿/赛泽里综合征的真实世界研究：一项 EORTC CLTG 研究。
Br J Dermatol. 2024 Aug 14;191(3):419-427. doi: 10.1093/bjd/ljae152.
4
Use of Pegylated Interferon Alpha-2a in Cutaneous T-cell Lymphoma: A Retrospective Case Collection.聚乙二醇干扰素 α-2a 在皮肤 T 细胞淋巴瘤中的应用：回顾性病例集。
Acta Derm Venereol. 2023 Oct 30;103:adv10306. doi: 10.2340/actadv.v103.10306.
5
EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome - Update 2023.EORTC 共识推荐的蕈样肉芽肿/赛泽里综合征治疗方案 - 2023 年更新版。
Eur J Cancer. 2023 Dec;195:113343. doi: 10.1016/j.ejca.2023.113343. Epub 2023 Sep 18.
6
Ultrahypofractionated Low-Dose Total Skin Electron Beam in Advanced-Stage Mycosis Fungoides and Sézary Syndrome.超分割低剂量全身电子束治疗晚期蕈样肉芽肿和塞扎里综合征
Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):164-170. doi: 10.1016/j.ijrobp.2023.02.052. Epub 2023 Mar 8.
7
Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced cutaneous T-cell lymphoma.晚期皮肤T细胞淋巴瘤患者对同时使用brentuximab vedotin和超分割低剂量全身皮肤电子束放疗的近乎完全缓解。
Br J Dermatol. 2023 Jan 23;188(1):145-146. doi: 10.1093/bjd/ljac012.
8
Low-dose total skin electron beam therapy plus oral bexarotene maintenance therapy for cutaneous T-cell lymphoma.低剂量全身电子束照射联合口服贝沙罗汀维持治疗皮肤 T 细胞淋巴瘤。
J Dtsch Dermatol Ges. 2022 Mar;20(3):279-285. doi: 10.1111/ddg.14657. Epub 2022 Jan 5.
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy.低剂量放疗逆转肿瘤免疫荒漠化并克服免疫治疗抵抗。
Cancer Discov. 2022 Jan;12(1):108-133. doi: 10.1158/2159-8290.CD-21-0003. Epub 2021 Sep 3.
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Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway.辐射诱导的免疫和毒性：cGAS-STING 通路的多功能性。
Front Immunol. 2021 May 17;12:680503. doi: 10.3389/fimmu.2021.680503. eCollection 2021.