Amoori Neda, Cheraghian Bahman, Amini Payam, Alavi Seyed Mohammad
Abadan University of Medical Sciences, Abadan, Iran.
Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iran J Public Health. 2024 Nov;53(11):2451-2461. doi: 10.18502/ijph.v53i11.16947.
Tuberculosis (TB) and infection of Hepatitis C virus (HCV) have appeared as major public health problems. The present systematic review and meta-analysis aimed at determining the relationship between TB and the risk of HCV infection.
Google Scholar, Embase, Medline, Pubmed, web of sciences (ISI), and Scopus were searched until March 2022. The pooled ORs of HCV in patients with TB were calculated utilizing the random-effect model with a 95% confidence interval (CI). test was utilized for evaluating the heterogeneity. To check publication bias Egger and Beggs' tests were used.
From among 1500 articles from 2006 to 2020, 13 studies were examined and analyzed based on the inclusion/exclusion criteria. The overall risk of HCV infection in patients with TB was (OR: 1.34, 95% CI: 1.10-1.63, =0.001). According to the type of the countries subgroup analysis, the risk of HCV infection in patients with TB in developing countries was (OR: 1.95, 95% CI: 1.00-3.80), which was higher than the risk in developed countries (OR: 1.47, 95% CI: 1.42-1.52). In addition, the risk of hepatitis C infection in men compared to women (OR: 1.84, 95% CI: 1.75-1.94, =0.001) and in age groups over 65 yr compared to other age groups (OR: 1.46, 95% CI: 0.98-2.16) was significantly higher.
The results of this study emphasized the importance of screening HCV in patients with TB. Being aware of the presence or absence of HCV in these patients can contribute to their effective treatment.
结核病（TB）和丙型肝炎病毒（HCV）感染已成为主要的公共卫生问题。本系统评价和荟萃分析旨在确定结核病与HCV感染风险之间的关系。
检索了谷歌学术、Embase、Medline、Pubmed、科学网（ISI）和Scopus，检索截至2022年3月。采用随机效应模型计算结核病患者中HCV的合并比值比（OR），并给出95%置信区间（CI）。使用I²检验评估异质性。采用Egger检验和Beggs检验检查发表偏倚。
在2006年至2020年的1500篇文章中，根据纳入/排除标准对13项研究进行了审查和分析。结核病患者中HCV感染的总体风险为（OR：1.34，95%CI：1.10-1.63，I²=0.001）。根据国家亚组分析类型，发展中国家结核病患者中HCV感染的风险为（OR：1.95，95%CI：1.00-3.80），高于发达国家的风险（OR：1.47，95%CI：1.42-1.52）。此外，男性丙型肝炎感染风险与女性相比（OR：1.84，95%CI：1.75-1.94，I²=0.001）以及65岁以上年龄组与其他年龄组相比（OR：1.46，95%CI：0.98-2.16）显著更高。
本研究结果强调了对结核病患者进行HCV筛查的重要性。了解这些患者中是否存在HCV有助于他们的有效治疗。
