一例具有多方面特征的肾上腺皮质癌罕见病例。
An Unusual Case of Adrenocortical Carcinoma with Multiple Facets.
作者信息
Tan Jie En, Tan Florence Hui Sieng, Kuan Yueh Chien, Chan Pei Lin, Yusri Yusuf
机构信息
Endocrine Unit, Department of Medicine, Sarawak General Hospital, Ministry of Health, Malaysia.
Pathology Department, Sarawak General Hospital, Ministry of Health, Malaysia.
出版信息
J ASEAN Fed Endocr Soc. 2024;39(2):92-96. doi: 10.15605/jafes.039.02.16. Epub 2024 Sep 3.
Adrenocortical carcinoma (ACC) is a rare malignant tumour from the adrenal cortex. Half of the cases are functional, with ACTH-independent autonomous cortisol production being the most common. It is rare for ACC to present with markedly elevated metanephrine levels, characteristic of pheochromocytoma. We report a case of a large functioning adrenal tumour with overlapping biochemical features of ACC and pheochromocytoma. Biopsy confirmed the histopathological diagnosis of metastatic ACC.
肾上腺皮质癌（ACC）是一种源自肾上腺皮质的罕见恶性肿瘤。半数病例具有功能性，其中以不依赖促肾上腺皮质激素（ACTH）的自主性皮质醇分泌最为常见。肾上腺皮质癌出现甲氧基肾上腺素水平显著升高的情况较为罕见，而这种情况是嗜铬细胞瘤的特征。我们报告一例具有肾上腺皮质癌和嗜铬细胞瘤重叠生化特征的大型功能性肾上腺肿瘤病例。活检证实了转移性肾上腺皮质癌的组织病理学诊断。
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