通过增强血红蛋白亲和力和抑制缺氧诱导因子-2α（HIF-2α）对线粒体疾病进行治疗性低氧处理 - Suppr

Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α.

作者信息

Wang Hong, Miranda Maria, Marutani Eizo, Lichtenegger Paul, Wojtkiewicz Gregory R, Ichinose Fumito, Mootha Vamsi K

机构信息

Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Broad Institute, Cambridge, Massachusetts, USA.

出版信息

J Clin Invest. 2024 Dec 2;134(23):e185569. doi: 10.1172/JCI185569.

DOI:10.1172/JCI185569

PMID:39621311

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11601899/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5984/11601899/5022c3eeb346/jci-134-185569-g089.jpg

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Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α.

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