LAPTM5: A Novel Target in an Old Fight against Tubular Senescence.
作者信息
Balzer Michael S
机构信息
Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany; and Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Berlin, Germany.
出版信息
J Am Soc Nephrol. 2024 Dec 1;35(12):1624-1626. doi: 10.1681/ASN.0000000524. Epub 2024 Oct 15.
Abstract
摘要
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本文引用的文献
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Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD.溶酶体相关蛋白跨膜蛋白5、肾小管衰老与慢性肾脏病进展
J Am Soc Nephrol. 2024 Dec 1;35(12):1655-1670. doi: 10.1681/ASN.0000000000000446. Epub 2024 Jul 30.
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Cellular senescence and kidney aging.细胞衰老与肾脏老化。
Clin Sci (Lond). 2023 Dec 22;137(24):1805-1821. doi: 10.1042/CS20230140.
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Targeting Senescent Cells as Therapy for CKD.靶向衰老细胞治疗慢性肾脏病。
Kidney360. 2024 Jan 1;5(1):142-151. doi: 10.34067/KID.0000000000000316. Epub 2023 Dec 5.
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Hallmarks of aging: An expanding universe.衰老的特征：一个不断扩大的领域。
Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.
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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis.单细胞分析衰老上皮细胞揭示了可靶向促进纤维化的机制。
JCI Insight. 2022 Nov 22;7(22):e154124. doi: 10.1172/jci.insight.154124.
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Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.单细胞分析突出了适应性或纤维化肾脏再生背后可用药理途径的差异。
Nat Commun. 2022 Jul 11;13(1):4018. doi: 10.1038/s41467-022-31772-9.
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Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease.TFEB 介导线粒体自噬对腺嘌呤诱导的慢性肾病小鼠肾小管间质纤维化的作用。
Biomed Pharmacother. 2021 Jan;133:110949. doi: 10.1016/j.biopha.2020.110949. Epub 2020 Nov 20.
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Cellular Senescence: Defining a Path Forward.细胞衰老：定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
9
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.急性肾损伤后导致肾脏加速衰老和慢性肾脏病的适应性修复不良机制。
Nat Rev Nephrol. 2015 May;11(5):264-76. doi: 10.1038/nrneph.2015.3. Epub 2015 Feb 3.
10
Cellular senescence: when bad things happen to good cells.细胞衰老：当好事发生在好细胞上时。 （注：原英文表述似乎不太符合正常逻辑，正常应该是不好的事情发生在细胞上才会导致衰老，这里按照字面意思翻译）
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. doi: 10.1038/nrm2233.
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