Zhou L J, Li Y Y, Zhang L Y, Zhang J
School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Zhonghua Xue Ye Xue Za Zhi. 2024 Oct 14;45(10):965-969. doi: 10.3760/cma.j.cn121090-20240327-00116.
Cuproptosis is a type of independent cell death form, that differs from apoptosis, necroptosis and ferroptosis. It is mediated by Copper (Cu), and mainly affects the lipoylation of proteases in the mitochondrial tricarboxylic acid (TCA) cycle and exhibits cytotoxicity through oligomerization; however, its specific mechanism, signal transduction process and regulation mode are still not clear. Mitochondria affect the sensitivity of cells to copper toxicity and play a central role in the occurrence and development of copper-related death. In recent years, though hematological tumors have achieved better remission through targeted therapy and immunotherapy, they are associated with high recurrence rates and poor prognoses. It is therefore imperative to find better prognostic indicators and new treatment ideas. This paper summarizes the interaction between Cu and mitochondria in the development of tumors and provides ideas for further exploration of the mechanism of copper death and coping with hematological tumors.
铜死亡是一种独立的细胞死亡形式，不同于凋亡、坏死性凋亡和铁死亡。它由铜（Cu）介导，主要影响线粒体三羧酸（TCA）循环中蛋白酶的脂酰化，并通过寡聚化表现出细胞毒性；然而，其具体机制、信号转导过程和调节方式仍不清楚。线粒体影响细胞对铜毒性的敏感性，在铜相关死亡的发生和发展中起核心作用。近年来，血液系统肿瘤虽通过靶向治疗和免疫治疗取得了较好的缓解，但复发率高且预后较差。因此，寻找更好的预后指标和新的治疗思路势在必行。本文总结了铜与线粒体在肿瘤发生发展中的相互作用，为进一步探索铜死亡机制及应对血液系统肿瘤提供思路。
