两个具有抗Pr1特异性的低离子强度依赖性自身凝集素的例子。

Two examples of low ionic strength-dependent autoagglutinins with anti-Pr1 specificity.

作者信息

O'Neill P, Shulman I A, Simpson R B, Halima D, Garratty G

出版信息

Vox Sang. 1986;50(2):107-11. doi: 10.1111/j.1423-0410.1986.tb04856.x.

DOI:10.1111/j.1423-0410.1986.tb04856.x

Abstract

Two low ionic strength-dependent autoagglutinins were studied and found to have anti-Pr1 specificity. This specificity was determined by studies with enzyme-treated and neuraminidase-treated human red blood cells (RBCs), animal RBCs and chemically-modified sialoglycoproteins, all suspended in a low ionic strength solution (LISS). Both IgM complement-binding cold agglutinins had a wide thermal range and caused in vitro hemolysis of some LISS-suspended RBCs at 37 degrees C. Compatible blood was found for these patients by using techniques that did not employ LISS.

摘要

研究了两种低离子强度依赖性自身凝集素，发现它们具有抗Pr1特异性。通过对酶处理和神经氨酸酶处理的人红细胞（RBC）、动物红细胞和化学修饰的唾液糖蛋白进行研究来确定这种特异性，所有这些都悬浮在低离子强度溶液（LISS）中。两种IgM补体结合冷凝集素都有较宽的温度范围，并在37℃时导致一些悬浮在LISS中的红细胞发生体外溶血。通过使用不采用LISS的技术为这些患者找到了相容的血液。