Liu Zixian, Lin Zexin, Chen Yingqi, Lu Mincheng, Hong Weisheng, Yu Bin, Liu Guanqiao
Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
J Cell Mol Med. 2024 Dec;28(23):e70247. doi: 10.1111/jcmm.70247.
The phenomenon of brain-bone crosstalk pertains to the intricate interaction and communication pathways between the central nervous system and the skeletal system. Disruption in brain-bone crosstalk, particularly in disorders such as osteoporosis, can result in skeletal irregularities. Consequently, investigating and comprehending this communication network holds paramount importance in the realm of bone disease prevention and management. In this study, we found that Staphylococcus aureus lipoteichoic acid promoted the conversion of arachidonic acid to PGE2 by interacting with TLR2 receptors acting on the surface of microglial cells in the pituitary gland, leading to the upregulation of COX-2 expression. Subsequently, PGE2 bound to the EP4 receptor of growth hormone-secreting cells and activated the intracellular CREB signalling pathway, promoting GH secretion and ameliorating age-related bone loss.
脑-骨串扰现象涉及中枢神经系统与骨骼系统之间复杂的相互作用和通讯途径。脑-骨串扰的破坏，尤其是在骨质疏松症等疾病中，会导致骨骼异常。因此，研究和理解这种通讯网络在骨病预防和管理领域至关重要。在本研究中，我们发现金黄色葡萄球菌脂磷壁酸通过与作用于垂体小胶质细胞表面的TLR2受体相互作用，促进花生四烯酸转化为PGE2，导致COX-2表达上调。随后，PGE2与生长激素分泌细胞的EP4受体结合并激活细胞内CREB信号通路，促进生长激素分泌并改善与年龄相关的骨质流失。
