Campins-Romeu Marina, Conde-Sardón Rebeca, Sastre-Bataller Isabel, Morata-Martínez Carlos, Losada-López Mireya, León-Guijarro José Luís, Raga-Rodríguez Luis, Pérez-García Julia, Gutiérrez-Martín Antonio, Lozano Andrés M, Baviera-Muñoz Raquel, Martínez-Torres Irene
Movement Disorders Unit, Department of Neurology, Hospital La Fe, Valencia, Spain.
Unit of Functional Neurosurgery, Department of Neurosurgery, Hospital La Fe, Valencia, Spain.
NPJ Parkinsons Dis. 2024 Dec 2;10(1):230. doi: 10.1038/s41531-024-00843-7.
Idiopathic Parkinson's Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion. Between June 2021 and October 2023, twelve PD patients underwent the procedure, with primary outcomes focused on safety and motor improvements after six months. Results indicated significant motor improvements, with over 50% reduction in tremor, rigidity, and bradykinesia, while balance and gait remained stable. Quality of life also improved. Side effects were generally mild and transient, though some patients experienced involuntary movements, managed through medication adjustments. Despite limitations, this technique appears to offer a promising, less-invasive alternative for managing PD symptoms with a favorable risk-benefit profile. Further research is necessary to refine the procedure and assess long-term outcomes.
特发性帕金森病（PD）是一种神经退行性疾病，其特征为震颤、僵硬、运动迟缓及姿势不稳。磁共振引导下的丘脑底核（STN）高强度聚焦超声（MRgFUS）作为一种微创手术选择正逐渐得到认可。本研究评估单侧MRgFUS丘脑底核切开术的安全性和有效性，旨在创建最小的有效损伤灶。在2021年6月至2023年10月期间，12例帕金森病患者接受了该手术，主要结局指标聚焦于六个月后的安全性和运动改善情况。结果显示运动功能有显著改善，震颤、僵硬和运动迟缓减轻超过50%，而平衡和步态保持稳定。生活质量也有所提高。副作用通常较轻且为一过性，不过一些患者出现了不自主运动，通过调整药物得以控制。尽管存在局限性，但这项技术似乎为管理帕金森病症状提供了一种有前景的、侵入性较小的替代方法，且风险效益比良好。有必要开展进一步研究以完善该手术并评估长期结局。
